Application of Placenta-Derived Exosomes in the Diagnosis of Fetal Growth Restriction

doi:10.12280/gjszjk.20220470

Abstract

Abstract:

The specific placenta-derived exosomes are important mediums for the communication between cells at the mother-to-fetus interface. During pregnancy, the placenta releases a large number of exosomes that promote the growth and development of embryos. These exosomes contain proteins, lipids, microRNAs, etc. As a kind of bioactive substances in exosomes, microRNAs participate in the occurrence and development of fetal growth restriction (FGR). Therefore, microRNAs may play an important role in the early diagnosis, clinical treatment and prognosis of diseases. In addition, the placental alkaline phosphatase (PLAP) and cell-free DNA (cfDNA) derived from exosome can also be used as specific markers in the clinical diagnosis of FGR. FGR is one of the common complications in obstetrics, which is the second leading cause of perinatal death. Therefore, early etiological diagnosis is extremely important. This article introduces the function of placenta-derived exosome and reviews its application in clinical diagnosis of FGR.

Key words: Exosomes, Fetal growth retardation, Placenta, Pregnancy, Alkaline phosphatase, MicroRNAs

LI Meng, WU Ya-mei, LI Jia-wen, ZHENG Xiao-min, YING Hao, HUANG Lu. Application of Placenta-Derived Exosomes in the Diagnosis of Fetal Growth Restriction[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(2): 156-160.

Figures/Tables 2

References 29

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