Association of Intestinal Flora with Male Infertility

doi:10.12280/gjszjk.20220579

Abstract

Abstract:

The intestinal flora, with a large number and a wide variety of categories, plays an irreplaceable role in human immunity, metabolism, and neuromodulation. Studies have shown an inextricable link between gut microbiota and male infertility. The intestinal flora of male infertility patients is related to the inflammatory response, metabolic regulation, neuromodulation and erectile dysfunction, and may affect male fertility through endotoxemia, energy metabolism, short-chain fatty acids, insulin resistance, etc. In addition, there have been a small number of studies on the clinical practice of dietary modification and supplementation of probiotics to regulate the intestinal flora in the treatment of some diseases. For example, the oral probiotics combined with L-carnitine can reduce the rate of sperm DNA fragmentation in obese men, which provides new ideas for the treatment of male infertility. In this paper, the association between intestinal flora and male infertility was summarized. The discussion of the role of intestinal flora in male infertility will be helpful for improving the clinical treatment options.

Key words: Gastrointestinal microbiome, Infertility, male, Disturbances of the microflora, Erectile dysfunction, Inflammation, Metabolic disorders

HU Rong, XIE Lei, ZHANG Li-hong, HU Jun-ping. Association of Intestinal Flora with Male Infertility[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(3): 236-239.

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