Therapeutic Role of the Mesenchymal Stem Cell-Derived Exosome in Repairing Endometrial Injury

doi:10.12280/gjszjk.20240565

Abstract

Abstract:

The endometrium could be damaged during various uterine cavity operations, which manifestes as adhesions and thinning of the endometrium. Endometrial injury can lead to reduced menstrual flow, amenorrhea, and even affect fertility. At present, there are very limited effective treatments for the moderate to severe endometrial injury in clinical practice. Mesenchymal stem cells (MSCs), as a type of stem cell with multipotent differentiation potential, have shown the great potential in tissue repair and regenerative medicine through their differentiation and secretion of MSCs derived exosome. In this article, we elaborate on the treatment effects of various sources of MSCs and MSCs derived exosome on endometrial injury and the underlying mechanisms, and analyze their clinical prospects and research directions, providing new treatment ideas for the clinical treatment of endometrial injury.

Key words: Mesenchymal stem cells, Endometrium, Tissue adhesions, Exosomes, Regenerative medicine, Therapy

WEN Bi-chao, MA Yu-zhen. Therapeutic Role of the Mesenchymal Stem Cell-Derived Exosome in Repairing Endometrial Injury[J]. Journal of International Reproductive Health/Family Planning, 2025, 44(3): 236-241.

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