Abstract: The rapid development of society leads to the change of people′s birth and life concept. Many women are delaying their age of childbearing to pursue educational and career goals, personal pursuit and others. With the full liberalization of two-child policy in China and the wide use of assisted reproductive technology (ART), the desire of the advanced couples to get their children has already been met as far as possible. The social phenomenon of the " I am born when you are old" will be a social concern in the next ten years. However, the implementation of ART for the advanced couples exists the reducing effectiveness, increasing cost, increasing health risks of the mother and the offspring, reducing quality of parents and even the  children′s interests are affected. Therefore, the setting age limit for ART is beneficial to society. It is a tricky problem for reproductive doctors and gynecologists how to face rationally and deal with the fertility require of those advanced couples.

Key words:  Age factors, Reproductive technology, assisted, Ethics, medical