Abstract: Objective：To observe the clinical efficacy of Ruyijinhuang Pulvis in treatment of facititial panniculitis following intramuscular injection of progesterone. Methods：Using cohort study, 63 facititial panniculitis patients in line with inclusive criteria were randomly assigned to the treatment group (treated with Ruyijinhuang Pulvis, 31 cases) and the control group (treated with Magnesium sulfate, 30 cases), 2 cases dropped. These facititial panniculitis were followed by the progesterone treatment during their in vitro fertilization-embryo transfer(IVF-ET) or frozen embryo transfer(FET) cycles. Scored symptoms of facititial panniculitis (tissue swelling, induration and rash) were observed before and after treatment. The data was analyzed by SPSS 18.0. Results：All patients were treated for 3 courses of treatment. The therapeutic effect at the end of each course was compared between two groups. There was significant difference in the total therapeutic effect between two groups (Z values were -4.064, -2.965 and -4.554 for three courses, all P＜0.05). Conclusions：Ruyijinhuang Pulvis could significantly improve clinical symptom of facititial panniculitis and promote the recovery.

Key words: Ruyi jinhuang powders, Panniculitis, Progestins, Factitial panniculitis