Abstract: Many etiologies attribute to the recurrent spontaneous abortion (RSA). Nowadays, the prethrombotic state and immunological factors have aroused more and more attention. However, it is difficult for us to treat the RSA related to dysimmunity or prethrombotic state. Usually, prednison, ciclosporin, immune globulin and lipid emulsion can be used in those women with abnormal lymphocyte, autoantibody and abnormal complement system. Prednison, hydroxychioroquine and immune globulin are used in those woman with the positive lupus screening test, and abnormal anti-SSA, anti-SSB and anti-dsDNA. Ciclosporin and immune globulin can be used when the blocking antibody is negative, while aspirin and low molecular heparin used when the coagulation indicator is abnormal and the antiphospholipid antibody is positive. Most of these drugs are out of their scopes when they are used in RSA. However, a great deal of clinical trials have proved that RSA women can authentically benefit from these drugs. We discussed the advantages and disadvantages of these drugs when used in RSA women, including the mechanism and clinical effects.

Key words: Abortion, habitual, Prethrombotic state, Thrombosis, Immune system, Therapy