Abstract:  Objective：To explore the relationship between chromosomal polymorphism of the infertile couples and the outcomes of IVF/ICSI-ET. Methods: The chromosome karyotype analysis of 1 318 infertile couples received IVF/ICSI-ET was performed in our center from September 2015 to November 2016. The couples with either male or female chromosome polymorphism were enrolled as the study group，while the couples with normal chromosome karyotypes were served as the control group. The outcomes of IVF/ICSI-ET of two groups were compared. Results: The occurrence of miscarriage history in the study group was significantly higher than that in the control group (24.64% vs. 15.65%, P=0.007). The rate of high-grade blastocysts in the male polymorphic couple was significantly lower than that in the woman′s chromosomal polymorphism (18.11% vs. 29.03%, P=0.016) or the control group (18.11% vs. 23.81%, P=0.017). Conclusions: The infertile couples with chromosomal polymorphism have higher rate of previous miscarriage history, and the embryos from male chromosomal polymorphism  might have relatively low development potential. However, their outcomes of IVF/ICSI-ET are similar to those with normal chromosome karyotypes.

Key words: Polymorphism, genetic, Fertilization in vitro, Sperm injections, intracytoplasmic, Pregnancy outcome