Research Progress of CRISP2 Protein

doi:10.12280/gjszjk.20200672

Abstract

Abstract:

CRISPs (cysteine rich secretory proteins) family contains four members. CRISP2 is the only member expressed in testicles, with high tissue specificity. CRISP2 is expressed and secreted by spermatocytes. This process won′t be affected by androgen. CRISP2 scatters in the seminiferous epithelium and is located at the junction of spermatocytes and Sertoli cells, helping spermatocytes connect to Sertoli cells. Afterward, CRISP2 goes with round spermatids and elongated spermatids, combines to the tail and the acrosome in the head of spermatozoa. CRISP2 probably modulate the influx of Ca²⁺ by combining with RyR3. CRISP2 may also act in modulating other receptors like inhibiting K⁺ channels. Research indicates that CRISP2 participates in the maturation and capacitation of spermatozoon all along, and also works in sperm-oocyte fusion. In this review, we will focus on the expression and distribution of CRISP2 in testicles as well as its regulation and function.

Key words: CRISP2, Sperm-oocyte fusion, Sperm-ovum interactions, Infertility, male, Asthenozoospermia, TPX1

YAO Yu-tong, QI Cong, Dina Yeernuer, WU Shi-qi, MA Jie, LIU Qiang. Research Progress of CRISP2 Protein[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(4): 323-327.

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