Journal of International Reproductive Health/Family Planning ›› 2022, Vol. 41 ›› Issue (1): 1-5.doi: 10.12280/gjszjk.20210346
• Original Article • Next Articles
LI Wan-qing, HONG Ming-yun(), TANG Zhi-xia
Received:
2021-08-03
Published:
2022-01-15
Online:
2022-02-17
Contact:
HONG Ming-yun
E-mail:2006mingyun@sina.com
LI Wan-qing, HONG Ming-yun, TANG Zhi-xia. Clinical Study of Different Ovulation Induction Schemes in the Treatment of Patients with Expected Poor Ovarian Response[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(1): 1-5.
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组别 | 周期 | 年龄(岁) | 不孕时间(年) | BMI(kg/m2) | AMH(ng/mL) | 基础FSH(U/L) |
---|---|---|---|---|---|---|
A组 | 161 | 37.61±5.73 | 3.0(1.0,6.0) | 22.84±2.82 | 0.58±0.30 | 11.69±6.47 |
B组 | 300 | 38.55±5.46 | 3.0(1.0,7.0) | 22.98±2.76 | 0.54±0.31 | 11.96±6.62 |
C组 | 153 | 37.62±6.07 | 3.0(1.0,7.5) | 22.51±2.74 | 0.51±0.30 | 13.02±6.47 |
F或χ2 | 2.087 | 0.019 | 1.435 | 1.736 | 1.885 | |
P | 0.125 | 0.991 | 0.239 | 0.177 | 0.153 |
组别 | 周期 | 年龄(岁) | 不孕时间(年) | BMI(kg/m2) | AMH(ng/mL) | 基础FSH(U/L) |
---|---|---|---|---|---|---|
A组 | 161 | 37.61±5.73 | 3.0(1.0,6.0) | 22.84±2.82 | 0.58±0.30 | 11.69±6.47 |
B组 | 300 | 38.55±5.46 | 3.0(1.0,7.0) | 22.98±2.76 | 0.54±0.31 | 11.96±6.62 |
C组 | 153 | 37.62±6.07 | 3.0(1.0,7.5) | 22.51±2.74 | 0.51±0.30 | 13.02±6.47 |
F或χ2 | 2.087 | 0.019 | 1.435 | 1.736 | 1.885 | |
P | 0.125 | 0.991 | 0.239 | 0.177 | 0.153 |
组别 | 周期 | Gn用量 (IU) | Gn时间 (d) | 获卵数 (个) | MⅡ卵数 (个) | 可用胚胎数 (个) | 优质胚胎数 (个) | 受精率 | 卵裂率 | 周期取消率 |
---|---|---|---|---|---|---|---|---|---|---|
A组 | 161 | 2 238.66±799.97 | 7.94±2.28 | 2.41±1.36 | 2(1,2) | 1(1,2) | 1(0,1) | 77.90(289/371) | 92.73(268/289) | 21.74(35/161) |
B组 | 300 | 1 240.58±537.71* | 7.21±2.45* | 1.80±1.04* | 1(0,2)* | 1(1,2) | 1(0,1) | 75.76(400/528) | 94.00(376/400) | 22.67(68/300) |
C组 | 153 | 1 359.35±685.34* | 7.67±3.07 | 1.53±1.16*△ | 1(0,2)* | 1(1,1) | 1(0,1) | 77.62(163/210) | 92.02(150/163) | 32.68(50/153)*△ |
F或 χ2 | 129.647 | 4.672 | 22.794 | 32.859 | 3.333 | 1.028 | 0.652 | 0.858 | 6.609 | |
P | 0.000 | 0.010 | 0.000 | <0.001 | 0.189 | 0.598 | 0.722 | 0.651 | 0.037 |
组别 | 周期 | Gn用量 (IU) | Gn时间 (d) | 获卵数 (个) | MⅡ卵数 (个) | 可用胚胎数 (个) | 优质胚胎数 (个) | 受精率 | 卵裂率 | 周期取消率 |
---|---|---|---|---|---|---|---|---|---|---|
A组 | 161 | 2 238.66±799.97 | 7.94±2.28 | 2.41±1.36 | 2(1,2) | 1(1,2) | 1(0,1) | 77.90(289/371) | 92.73(268/289) | 21.74(35/161) |
B组 | 300 | 1 240.58±537.71* | 7.21±2.45* | 1.80±1.04* | 1(0,2)* | 1(1,2) | 1(0,1) | 75.76(400/528) | 94.00(376/400) | 22.67(68/300) |
C组 | 153 | 1 359.35±685.34* | 7.67±3.07 | 1.53±1.16*△ | 1(0,2)* | 1(1,1) | 1(0,1) | 77.62(163/210) | 92.02(150/163) | 32.68(50/153)*△ |
F或 χ2 | 129.647 | 4.672 | 22.794 | 32.859 | 3.333 | 1.028 | 0.652 | 0.858 | 6.609 | |
P | 0.000 | 0.010 | 0.000 | <0.001 | 0.189 | 0.598 | 0.722 | 0.651 | 0.037 |
组别 | 周期 | 年龄 (岁) | BMI (kg/m2) | 子宫内膜 厚度(mm) | 移植胚胎数 (个) | 优质胚胎 移植 |
---|---|---|---|---|---|---|
A组 | 120 | 37.93±5.38 | 23.32±3.56 | 10.12±2.14 | 1.43±0.51 | 95(79.17) |
B组 | 114 | 38.79±5.65 | 23.25±2.61 | 9.94±2.02 | 1.39±0.51 | 91(79.82) |
C组 | 65 | 38.09±5.70 | 22.73±2.71 | 9.85±2.42 | 1.48±0.53 | 49(75.38) |
F或 χ2 | 0.750 | 0.860 | 0.371 | 0.650 | 0.524 | |
P | 0.473 | 0.424 | 0.690 | 0.523 | 0.770 |
组别 | 周期 | 年龄 (岁) | BMI (kg/m2) | 子宫内膜 厚度(mm) | 移植胚胎数 (个) | 优质胚胎 移植 |
---|---|---|---|---|---|---|
A组 | 120 | 37.93±5.38 | 23.32±3.56 | 10.12±2.14 | 1.43±0.51 | 95(79.17) |
B组 | 114 | 38.79±5.65 | 23.25±2.61 | 9.94±2.02 | 1.39±0.51 | 91(79.82) |
C组 | 65 | 38.09±5.70 | 22.73±2.71 | 9.85±2.42 | 1.48±0.53 | 49(75.38) |
F或 χ2 | 0.750 | 0.860 | 0.371 | 0.650 | 0.524 | |
P | 0.473 | 0.424 | 0.690 | 0.523 | 0.770 |
组别 | 周期 | 着床率 | 生化妊娠率 | 临床妊娠率 | 流产率 |
---|---|---|---|---|---|
A组 | 120 | 23.98(41/171) | 10.00(4/40) | 30.00(36/120) | 22.22(8/36) |
B组 | 114 | 20.25(32/158) | 30.23(13/43)* | 26.32(30/114) | 30.00(9/30) |
C组 | 65 | 17.71(17/96) | 11.11(2/18) | 24.62(16/65) | 31.25(5/16) |
χ2 | 1.576 | 6.045 | 0.728 | 0.702 | |
P | 0.455 | 0.041 | 0.695 | 0.704 |
组别 | 周期 | 着床率 | 生化妊娠率 | 临床妊娠率 | 流产率 |
---|---|---|---|---|---|
A组 | 120 | 23.98(41/171) | 10.00(4/40) | 30.00(36/120) | 22.22(8/36) |
B组 | 114 | 20.25(32/158) | 30.23(13/43)* | 26.32(30/114) | 30.00(9/30) |
C组 | 65 | 17.71(17/96) | 11.11(2/18) | 24.62(16/65) | 31.25(5/16) |
χ2 | 1.576 | 6.045 | 0.728 | 0.702 | |
P | 0.455 | 0.041 | 0.695 | 0.704 |
[1] | Ubaldi FM, Rienzi L, Ferrero S, et al. Management of poor responders in IVF[J]. Reprod Biomed Online, 2005, 10(2):235-246. doi: 10.1016/s1472-6483(10)60946-7. |
[2] | Devine K, Mumford SL, Wu M, et al. Diminished ovarian reserve in the United States assisted reproductive technology population: diagnostic trends among 181,536 cycles from the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System[J]. Fertil Steril, 2015, 104(3):612-619. e3. doi: 10.1016/j.fertnstert.2015.05.017. |
[3] | 武学清, 孔蕊, 田莉, 等. 卵巢低反应专家共识[J]. 生殖与避孕, 2015, 35(2):71-79. doi: 10.7669/j.issn.0253-357X.2015.02.0071. |
[4] | Alviggi C, Andersen CY, Buehler K, et al. A new more detailed stratification of low responders to ovarian stimulation: from a poor ovarian response to a low prognosis concept[J]. Fertil Steril, 2016, 105(6):1452-1453. doi: 10.1016/j.fertnstert.2016.02.005. |
[5] | 邹林兵, 戴志俊, 张芳芳, 等. 首次体外受精-胚胎移植治疗周期为全部非优质胚胎的移植策略分析[J]. 中国妇产科临床杂志, 2020, 21(2):129-132. doi: 10.13390/j.issn.1672-1861.2020.02.005. |
[6] | Ferraretti AP, La Marca A, Fauser BC, et al. ESHRE consensus on the definition of ′poor response′ to ovarian stimulation for in vitro fertilization: the Bologna criteria[J]. Hum Reprod, 2011, 26(7):1616-1624. doi: 10.1093/humrep/der092. |
[7] | Papathanasiou A. Implementing the ESHRE ′poor responder′ criteria in research studies: methodological implications[J]. Hum Reprod, 2014, 29(9):1835-1838. doi: 10.1093/humrep/deu135. |
[8] | Humaidan P, Chin W, Rogoff D, et al. Efficacy and safety of follitropin alfa/lutropin alfa in ART: a randomized controlled trial in poor ovarian responders[J]. Hum Reprod, 2017, 32(3):544-555. doi: 10.1093/humrep/dew360. |
[9] | Zhen XM, Qiao J, Li R, et al. The clinical analysis of poor ovarian response in in-vitro-fertilization embryo-transfer among Chinese couples[J]. J Assist Reprod Genet, 2008, 25(1):17-22. doi: 10.1007/s10815-007-9187-9. |
[10] | Wang R, Lin S, Wang Y, et al. Comparisons of GnRH antagonist protocol versus GnRH agonist long protocol in patients with normal ovarian reserve: A systematic review and meta-analysis[J]. PLoS One, 2017, 12(4):e0175985. doi: 10.1371/journal.pone.0175985. |
[11] | He W, Li X, Adekunbi D, et al. Hypothalamic effects of progesterone on regulation of the pulsatile and surge release of luteinising hormone in female rats[J]. Sci Rep, 2017, 7(1):8096. doi: 10.1038/s41598-017-08805-1. |
[12] | Pilehvari S, ShahrokhTehraninejad E, Hosseinrashidi B, et al. Comparison Pregnancy Outcomes Between Minimal Stimulation Protocol and Conventional GnRH Antagonist Protocols in Poor Ovarian Responders[J]. J Family Reprod Health, 2016, 10(1):35-42. |
[13] | 张加盟, 易建平, 樊桂玲, 等. 拮抗剂方案和微刺激方案在预期低反应患者中的应用[J]. 中国妇幼保健, 2020, 35(13):2482-2485. doi: 10.19829/j.zgfybj.issn.1001-4411.2020.13.042. |
[14] | 李小兰, 张晓莉, 黄睿, 等. 卵泡期高孕激素状态下促排卵方案在高龄卵巢低反应患者中的治疗结局分析[J]. 生殖医学杂志, 2018, 27(12):1200-1204. doi: 10.3969/j.issn.1004-3845.2018.12.007. |
[15] | 周莉娜, 陈威, 吴煜, 等. 拮抗剂方案与微刺激方案对卵巢低反应患者体外受精-胚胎移植结局的比较[J]. 国际生殖健康/计划生育杂志, 2019, 38(5):374-377,388. doi: 10.3969/j.issn.1674-1889.2019.05.005. |
[16] | Bastu E, Buyru F, Ozsurmeli M, et al. A randomized,single-blind,prospective trial comparing three different gonadotropin doses with or without addition of letrozole during ovulation stimulation in patients with poor ovarian response[J]. Eur J Obstet Gynecol Reprod Biol, 2016, 203:30-34. doi: 10.1016/j.ejogrb.2016.05.027. |
[17] | Chen Q, Wang Y, Sun L, et al. Controlled ovulation of the dominant follicle using progestin in minimal stimulation in poor responders[J]. Reprod Biol Endocrinol, 2017, 15(1):71. doi: 10.1186/s12958-017-0291-0. |
[18] | Massin N. New stimulation regimens: endogenous and exogenous progesterone use to block the LH surge during ovarian stimulation for IVF[J]. Hum Reprod Update, 2017, 23(2):211-220. doi: 10.1093/humupd/dmw047. |
[19] | 张宏展, 熊风, 李观贵, 等. 重复玻璃化冻融胚胎移植后临床结局[J]. 生殖医学杂志, 2018, 27(7):642-646. doi: 10.3969/j.issn.1004-3845.2018.07.008. |
[20] | Roque M, Haahr T, Geber S, et al. Fresh versus elective frozen embryo transfer in IVF/ICSI cycles: a systematic review and meta-analysis of reproductive outcomes[J]. Hum Reprod Update, 2019, 25(1):2-14. doi: 10.1093/humupd/dmy033. |
[21] | 王含必, 汤鲜, 邓成艳, 等. 波塞冬分类标准下患者体外受精/卵胞质内单精子注射妊娠结局的影响因素[J]. 中华生殖与避孕杂志, 2019, 39(9):706-711. doi: 10.3760/cma.j.issn.2096-2916.2019.09.003. |
[22] | 周城, 孙琴, 程茜, 等. 卵巢低反应波塞冬分类年轻患者促排卵方案的选择[J]. 医学研究生学报, 2020, 33(9):948-951. doi: 10.16571/j.cnki.1008-8199.2020.09.010. |
[23] | 代玮, 胡琳莉. 非预期与预期卵巢低反应患者多周期助孕累积活产率的比较[J]. 郑州大学学报(医学版), 2021, 56(5):697-702. doi: 10.13705/j.issn.1671-6825.2020.01.022. |
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