Mitochondrial Abnormalities in Diminished Ovarian Reserve

doi:10.12280/gjszjk.20240358

Abstract

Abstract:

Diminished ovarian reserve (DOR) is a significant concern in the field of female reproductive health, characterized by a decrease in the quantity or quality of available eggs within the ovaries. Mitochondria serve as the powerhouses of the cell, and various cellular activities depend on the normal functioning of mitochondria. For the female reproductive system, mitochondrial dysfunction is closely associated with ovarian aging, poor oocyte quality, and diminished embryonic developmental potential. Mitochondrial dysfunction can impact the ovarian reserve through multiple mechanisms such as the decreased mitochondrial quantity, abnormal mitochondrial DNA copy number, mitochondrial DNA mutations/deletions, and mitochondrial autophagy. In this article, we discuss the effect of mitochondrial dysfunction in the pathophysiological mechanisms of DOR and DOR-related diseases.

Key words: Ovarian reserve, Mitochondria, Oxidative stress, Oocytes, Mitophagy

XU Qiang, ZHANG Man-li, LA Xiao-lin. Mitochondrial Abnormalities in Diminished Ovarian Reserve[J]. Journal of International Reproductive Health/Family Planning, 2025, 44(1): 54-58.

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