Advancements in Research on MicroRNAs Related to Insulin Resistance in Polycystic Ovary Syndrome

doi:10.12280/gjszjk.20240463

Abstract

Abstract:

Insulin resistance (IR) characterizes not only a universal clinical feature of polycystic ovary syndrome (PCOS), but also serves a significant role in its pathophysiology. PCOS and IR are closely related and mutually cause each other. The interaction between IR and PCOS creates a detrimental cycle. There was substantial progress in the study of microRNAs (miRNAs) roles in PCOS-linked metabolic disturbances. The degree of miRNAs expression is intrinsically associated with PCOS-IR. In this paper, we discuss the miRNAs-related etiopathogenesis of PCOS-IR.

Key words: Polycystic ovary syndrome, MicroRNAs, Insulin resistance, Phosphatidylinositol 3-kinases, Proto-oncogene proteins c-akt, Insulin receptor substrate proteins

JIA Sheng-xiao, SUN Miao, KUANG Hong-ying, XU Bo-ya. Advancements in Research on MicroRNAs Related to Insulin Resistance in Polycystic Ovary Syndrome[J]. Journal of International Reproductive Health/Family Planning, 2025, 44(1): 59-64.

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