Abstract:

Women of childbearing age are a group with the second highest incidence of essential thrombocythemia, and the reproductive challenges of this group have attracted clinical attention. We report a case of an infertile patient with essential thrombocythaemia who gave birth successfully through in vitro fertilization-embryo transfer (IVF-ET). The patient received IVF-ET due to primary infertility and ineffective ovulation induction. During the treatment, the medication regimen was adjusted multiple times due to abnormal platelet level. Aspirin alone before and after the first transplantation and aspirin combined with low molecular weight heparin calcium before and after the subsequent transplantation did not get successfully pregnancy. The treatment strategy was then adjusted to use firstly aspirin combined with interferon-α to reduce the platelet level. After platelet level was well controlled, aspirin combined with low molecular weight heparin calcium treatment was used before and after embryo transfer. After successful pregnancy, this regimen was continued until delivery. Ultimately, a successful live birth was achieved. By exploring the clinical characteristics, treatment methods and successful experience of this case, the key role of individualized treatment plan in improving the success rate of assisted pregnancy is emphasized.

Key words: Thrombocythemia, essential, Infertility, female, Fertilization in vitro, Embryo transfer, Therapy