Abstract: Objectives：To discuss the early diagnosis of non-simultaneous ectopic pregnancy and current treatment methods. Methods：Two cases with non-simultaneous bilateral tubal ectopic pregnancy in our reproductive medical center and three cases previously reported have been reviewed. Results：The contralateral delayed ectopic pregnancy might be easily ingnored while unilateral pregnancy has been confirmed，which often needs secondary surgery. Conclusions：For the infertile women in ART with tubal factors，removal of both follopian tubes might be a solution to exclude the potential non-simultaneous bilateral tubal ectopic pregnancy while unilateral salpingectomy is performed. Otherwise，carefully examination of contralateral tube in surgery and strictly follow up of serum β-HCG after surgery facilitate to discover the potential non-simultaneous pregnancy for those people want to save another tube.

Key words: Reproductive techniques, assisted, Pregnancy, ectopic, Pregnancy, tubal, Therapy, Chorionic gonadotropin, beta subunit, human