Abstract: Follicule鄄stimulating hormone（FSH）is the central hormone of female reproduction. This
gonadotropin is produced and secreted by the anterior pituitary gland as a glycoprotein. FSH evokes its
biological effects by interacting with a high affinity receptor（R）located on the plasma membrane of granulosa
cells in the ovary. The FSH receptor（FSHR）is a glycoprotein that belongs to the superfamily of G protein鄄
coupled receptors（GPCRs），and occupancy of the FSHR causes activation of signaling cascade downstream of
cAMP/PKA pathway. FSH can promote proliferation and differentiation of granulosa cells and synthesis of
sexual hormone.

Key words: Follicule stimulating hormone, cAMP/PKA pathway, Granulosa cells, Cyclic AMP鄄 dependent protein kinases