Table of Content

15 January 2011, Volume 30 Issue 1
Previous Issue    Next Issue
---
述评
热点问题
综述
讲座
论著
综述


For Selected:

Download Citations EndNote Ris BibTeX

Toggle Thumbnails

述评

Select

Male Climacteric Health—Controversies and Perspectives WANG Yi-fei. 2011, 30 (1):  1-4.  Abstract ( 2891 )   PDF (246KB) ( 7390 )   This commentary focused on the existing controversies about male climacteric and male climacteric syndrome, discussing on the following major topics one by one: definition and scope of male climacteric health, testosterone decline and male climacteric syndrome, as well as the rationale of testosterone supplement treatment. It is recommended to develop a whole lifespan systematic analysis and comprehensive intervention strategy for male climacteric health care and health promotion. Related Articles | Metrics

热点问题

Select

Update of Researches on Validation of Screening Scales for Late-onset Hypogonadism in Males ZHOU Shan-jie;GU Yi-qun. 2011, 30 (1):  5-9.  Abstract ( 2111 )   PDF (269KB) ( 7301 )   This paper discusses importance on the update and hotspot of researches on validation of AMS and ADAM both in domestic and overseas. Numerous researches validated the applicability and validity of different language editions of screening scales from several points of view and through several methods. The conclusions of majority researches believe AMS and ADAM to be one of good tools for LOH screening. Both scales have general applicability and higher validity. In addition, this paper points out the problems and shortcomings on the researches of validation of AMS and ADAM today. Related Articles | Metrics

综述

Select

The Mechanism and Epidemiological Research on Late鄄onset Hypogonadism in Males LI Hong－jun;GU Yi-qun 2011, 30 (1):  10-13.  Abstract ( 2570 )   PDF (257KB) ( 7650 )   With the rapid aging progression for the human being，more concern was focused on the research of late鄄onset hypogonadism（LOH）. In the review article，the mechanism and epidemiological research on LOH is sumarized. The mechanism of LOH is the combinated effects of primary and secondary factors， which achieved by many pathways to damage the secretion and bio鄄activity of androgen including the androgen level and androgen receptor（AR）. Morbidity，susceptibility and risk factors are reviewed including diseases and medication，obesity，untoward life style，environmental and genetic factors，psychological factor，social鄄 economic factors and cultural level. Related Articles | Metrics

Select

Late－onset Hypogonadism and Sexual Dysfunction SHANG Xue-un;HUA Xue-ian;HUANG Yu-eng 2011, 30 (1):  14-17.  Abstract ( 2662 )   PDF (255KB) ( 7430 )   Male late鄄onset hypogonadism（LOH）is a clinical and biochemical syndrome which is age鄄 associated with typically clinical symptoms and a deficiency in serum testosterone levels—lower than the recommend extent of healthy young adult males. Testosterone deficiency takes an important role in its pathogenesis. Testosterone deficiency is an significant factor which induces sexual dysfunction. Testosterone supplementary treatment（TST）can improve sexual function of patients with LOH in an extent. Related Articles | Metrics

Select

Late -onset Hypogonadism and Mental Illness LI Fei;MAO Xiang-ming;FENG Xian-gang 2011, 30 (1):  18-20.  Abstract ( 3270 )   PDF (218KB) ( 7372 )   With the development of society and economy，people gradually have realized the physiological role of testosterone from embryonic development to aging throughout the entire male physical activity and having a significant impact on the quality of life. As aging after the 40鄄year鄄old male，while the level of endogenous testosterone reduces，the male will be anxiety，panic anxiety，insomnia，apathy and a series of psychological performance disorders. Therefore，to further research the relationship between late鄄onset hypogonadism（LOH）and mental illness is necessary，and certainly for the prevention and treatment of senile mental mental illness. It is also very important，urgent and has important clinical significance. Related Articles | Metrics

Select

The Role of Late-onset Hypogonadism in Males in the Metabolic Syndrome GUAN Di;GU Yi-qun 2011, 30 (1):  21-25.  Abstract ( 2943 )   PDF (234KB) ( 7419 )   The main characteristics of the metabolic syndrome are visceral obesity, glucose intolerance, raised blood pressure, dyslipidaemia, inflammation and thrombosis. Low testosterone levels are associated with the metabolic syndrome closely. The metabolic syndrome is a clustering of risk factors predisposing to diabetes mellitus, atherosclerosis and cardiovascular morbidity and mortality. Cross鄄sectional epidemiological studies reported a direct correlation between plasma testosterone level and insulin sensitivity, and low testosterone levels are associated with an increased risk of type 2 diabetes mellitus. Lower total testosterone and sex hormone鄄binding globulin predict a higher incidence of the metabolic syndrome. There were also some clinical trials showing improvements in insulin resistance and glycaemic control with testosterone supplement therapy. Administration of testosterone to hypogonadal men reverses the unfavorable risk profile for the development of diabetes and atherosclerosis. The lower serum T level should be an element in the definition of the metabolic syndrome. Related Articles | Metrics

Select

Effects of Testosterone on Body Composition: Bone, Muscles and Lipid Metabolism HONG Kai;JIANG Hui 2011, 30 (1):  26-28.  Abstract ( 3994 )   PDF (183KB) ( 7539 )   Androgen is related with male bone mass, muscles and lipid metabolism. Testosterone is the key point to male bone health. Testosterone level in normal range would keep the bone density. Testosterone would also increase lean body and muscles strength. Meantime, it could control the lipid volume, especially abdomen lipid. Testosterone supplement therapy for low testosterone level patients would keep bone density, increase lean body mass and muscle strength and decrease body lipid. Related Articles | Metrics

讲座

Select

Advances of Basic Research of Late-onset Hypogonadism GAO Yong;XIANG Peng;DENG Chun-hua 2011, 30 (1):  34-38.  Abstract ( 2375 )   PDF (290KB) ( 7384 )   In recent years，late鄄onset hypogonadism （LOH）attracted people’s attention. The basic research of late鄄onset hypogonadism became research hot point. When men age，the number reduction and the functional decline of leydig cells is the core of the disease pathogenesis. The synthesis of testosterone in leydig cells is a series of enzymatic reactions controlled by a variety of transcription factors. Stem leydig cells differentiate into leydig cells. Stem leydig cells is very important for the research of the development and differentiation of Leydig cell and the new treatment of LOH. At present，stem leydig cells has been successfully isolated and identified，but this research area is still in the initial stage. The transplantation of leydig cells and stem leydig cells become the most promising way for new treatment research of LOH. Related Articles | Metrics

论著

Select

Effects of the Cryoprotectants Containing Estrogen on the Sperm Vitrified Cryopreservation LI Feng-hua;ZHAO Jun-li;JIA Shao-tong;WANG Hong-yan 2011, 30 (1):  39-41.  Abstract ( 3049 )   PDF (246KB) ( 7333 )   Objective: To explore the different effect of different cryoprotective containing estrogen on human spermatozoa. Methods: Each semen came from healthy patient will be divided into five copies, one copy was as control group, and the other four copies were as experimental group which were preserved by cryopreservativemedium泽（悦PMs）with glycerol, glycerol鄄eygyolk鄄sodium（GYC）, glycerol+estrogen and GYC+ estrogen. The cryoprotective effects of human spermatozoa were evaluated by conventional semen analysis, viability, motility, morphology and spermatozoa hypo鄄osmotic swelling rate （HOSR）. Results: During the procedure of cryoprotective and thawing, different CPM had different protective effect on the spermatozoa, which showed significantly different（P<0.01）, and glycerol and glycerol鄄eygyolk鄄sodium（GYC）group were decreased significantly than the other two groups（P<0.01）. The parameters in the the group of GYC+E2 were significantly higher than those of in the group of glycerol +E2 （P<0.01）. Conclusions: The cryoprotectant containing estrogen can increase the function of cryopreserved sperm. Related Articles | Metrics

Select

Effect of IGF-Ⅱ and EGF on the Development of ICR Mouse Embryos in Vitro PAN Jing;LIU Yang;ZHOU Hong-lin 2011, 30 (1):  42-44.  Abstract ( 2160 )   PDF (209KB) ( 7292 )   Objective: To investigate the effection of IGF-域and EGF on the development of ICR mouse preimplantation embryos in the CZB culture medium with glucose and insulin in vitro. Methods: 淤Experiment1: One-cell ICR mouse embryos were cultured in the CZB medium with glucose and insulin supplemented with IGF- 域（0, 0.1, 1, 10 and 100 滋g/L）, and a separate control group of CZB medium was established .于Experiment 2: One-cell ICR mouse embryos were cultured in the CZB medium with glucose, insulin and IGF-域（0.1 滋g/L） supplemented with EGF （0, 0.1, 1, 10 and 100 滋g/L）, and a separate control group of CZB medium was established. Blastocyst rates, hatched blastocyst rates and the cell numbers of blastocysts were counted. Results: ①Experiment1: IGF-Ⅱ（0 μg/L）increased the rate of blastocyst, hatched blastocyst and the total cell numbers of blastocyst compared with control group（P＜0.05）. IGF-Ⅱat a dose of 100 μg/L decreased the rate of blastocyst, hatched blastocyst and the total cell numbers of blastocyst compared with the other groups（P＜0.05）. IGF-Ⅱ at a dose of 0.1 μg/L greatly increased the total cell numbers of blastocyst（P＜0.05）. ②Experiment 2: EGF（0 μg/L） increased the rate of blastocyst, hatched blastocyst and the total cell numbers of blastocyst compared with control group（P＜0.05）. EGF at doses of 0.1, 1 and 10 μg/L increased the rate of blastocyst and hatched blastocyst compared with EGF at doses of 0 and 100 μg/L（P＜0.05），and EGF at a dose of 0.1 μg/L had the highest rate of hatched blastocyst（P＜0.05）. EGF at a dose of 0.1 μg/L increased the total cell numbers of blastocyst compared with EGF at a dose of 0μg/L（P＜0.05）. EGF at a dose of 100 μg/L had the lowest rate of the total cell numbers of blastocyst（P＜0.05）. Conclusions:淤IGF-域渊1, 10 滋g/L冤, glucose and insulin showed no significant effect of suppression or promotion among. 于EGF 渊1, 10 滋g/L冤in CZB medium with glucose, insulin and IGF-域could involves in the regulationof differentiation of embryonic cells but no proliferation. 盂IGF-域and EGF at a dose of 0.1 滋g/L is best for cell culture concentration. 榆IGF-域and EGF at a dose of 100 滋g/L have inhibition effect on embryonic cells. Related Articles | Metrics

Select

Enhance the Management of IUD Services in Family Planning Clinics at County and Township Level in Western China China JIA Xian-jie;YOU Ding-yun;GAO Yi-fei;ZHOU Jie;SU Cun-mei;YANG Yao;ZHAO Min;ZHANG Kai-ning. 2011, 30 (1):  50-53.  Abstract ( 3002 )   PDF (279KB) ( 7388 )   Objective: 1. To identify the key elements of IUD（intrauterine devices）services in family planning（云孕）clinics at county and township level in western China in order to explore the reasons leading to a higher failure rate of IUD use compared with the lower level FP clinics. 2. To provide recommendations for enhancing FP service quality at the county level. Methods：Using situation analysis, a cross鄄sectional study was undertaken in FP clinics within three counties, which were randomly selected out of 129 counties in Yunnan province. Both quantitative and qualitative methods were adopted in data collection and analysis. Results: Averagely，6.17依2.55 types of IUDs were used in FP clinics at county level, while 4.08依0.92 types of IUDs were used at township level , which showed a significant difference（Z=2.37，P=0.023）. Compared with the clinics at township level, lower proportion of IUDs were used in FP clinics at county level recommended by national committee based on evidences of lower failure rate. Moreover, certain types of IUD being reported a high failure rate were still used in county level clinics. The annual number of IUD insertion cases provided by a county FP clinics was averagely 129.83依47.42, while the number was reported 288.75依35.18 at town level, which showed a significant difference （F=22.26，P<0.000 1）. It was implicated that weaknesses in service management existed, such as the absence of effective communication between service providers and managers, which may contribute to the use of inappropriate types of IUD and undermine the quality of services. Conclusions: FP clinics at county level in western China should improve service quality by controlling the types of IUDs properly and strengthening the IUD services management. Related Articles | Metrics

综述

Select

Study on the Relationship of Epididymis-specific Protein and Sperm Function HAN Li-yuan;YU He-ming. 2011, 30 (1):  54-57.  Abstract ( 2065 )   PDF (245KB) ( 7290 )   Charactering the sperm specific proteins is to elucidate the function in the process of reproduction and to develop them as effective targets for reproductive regulation. Mammalian sperm after spermiogenisis in testis seminiferous tubules, although they are tadpole鄄like, are neither able to swim nor to fertilize the egg. Sperm must undergo modification in epididymis to be mature, which is called epididymal sperm maturation. This process mainly includes the sperm membrane protein modification. During sperm traveling through the epididymis tubes, some proteins are removed away, some are binding on, and some proteins are glycosylated or phosphorylated. Therefore, the identification of epididymal protein, especially the epididymal鄄specific protein, is one of the most important points to reveal the function of sperm. The function of epididymal鄄specific protein, especially on sperm maturation and sperm protection, is reviewed in this paper. Related Articles | Metrics

Select

Application of SpermChromatin Integrity Test in Assisted Reproductive Technology JIANG Huan-huan;CAO Yun-xia;HE Xiao-jin 2011, 30 (1):  58-60.  Abstract ( 2635 )   PDF (221KB) ( 7302 )   As there is an increase of researches concerning andrology，the assessment of sperm has come to the cellular and molecular level. Sperm chromatin integrity is a new marker of male fertility. It affects the fertilization，embryo quality，pregnancy and so on. Accordingly，it is necessary to detect sperm chromatin integrity and adopt certain measures to obtain those sperm with less or no damage，which this can improve the outcome of ART. Sperm chromatin structure assay（SCSA）is one of the common techniques to measure sperm chromatin integrity. This review focuses on the mechanism and detection of sperm chromatin integrity damage， its association with reproductive outcomes，and relevant treatment strategies in assisted reproductive technology Related Articles | Metrics

Select

Assessment of Sperm DNA Integrity and Clinical Management SONG Xue-ru;JIANG Shan;BAI Xiao-hong;YUE Tian-fu 2011, 30 (1):  61-64.  Abstract ( 2193 )   PDF (236KB) ( 7408 )   The male fertility is affected by many factors and sperm DNA damage is one of the hot spots in ART. Spermatozoa mitochondria and nucleus DNA damage have negative effects on normal fertilized process，pronucleus shaping，implantation and offspring health. At present，sperm DNA damage can be detected by more and more methods, although none of these provides an ideal method to assess sperm DNA integrity, and each has its clinical application，which are more stable and more sensitive than the conventional analysis of semen. It is necessary to assess sperm DNA damage before ICSI. Assessment of sperm DNA damage is considered to be a new evaluation of semen quality and fertility prediction indicators. This article reviews the studies on detection of sperm DNA damage and association with reproductive outcomes. Related Articles | Metrics

Select

cAMP/PKA Pathway in FSH-Induced Granulosa Cells Proliferation and Differentiation CHEN Yue-qun;HUANG He-feng 2011, 30 (1):  65-68.  Abstract ( 2475 )   PDF (283KB) ( 7374 )   Follicule鄄stimulating hormone（FSH）is the central hormone of female reproduction. This gonadotropin is produced and secreted by the anterior pituitary gland as a glycoprotein. FSH evokes its biological effects by interacting with a high affinity receptor（R）located on the plasma membrane of granulosa cells in the ovary. The FSH receptor（FSHR）is a glycoprotein that belongs to the superfamily of G protein鄄 coupled receptors（GPCRs），and occupancy of the FSHR causes activation of signaling cascade downstream of cAMP/PKA pathway. FSH can promote proliferation and differentiation of granulosa cells and synthesis of sexual hormone. Related Articles | Metrics

Select

The Pharmacologic Actions Progression of Quercetin on Estrogen Related Diseases YANG Ying;CAO Yang;ZHANG Ting-ting;ZHU Yan;CAO Lin 2011, 30 (1):  69-72.  Abstract ( 3795 )   PDF (246KB) ( 7517 )   Quercetin is one of flavones in phytoestrogen .Recently ,there have many researches about quercetin, and most of them are related with estrogen correlative diseases,such as breast cancer , osteoporosis and prostate cancer, et al. In these diseases, there may have many effects, including promoting cell apoptosis , controlling osteoclasts differentiation,regulation estrogen metabolism in vivo and effecting tumor cell growth progression ,involving adhesion ,invasion and angiopoiesis .Comparing with other flavones ,quercetin has its own distinct character. Many mechanisms may explain quercetin pharmacologic actions, mainly to sum up for two aspests: 淤Expression of antioxidation: inducing cell apoptosis and regulating estrogen metabolism. 于 Regulation of estrogens: as a estrogen receptor (ER) modulator,quercetin restrains tumor cell growth by influencing down鄄stream substrate of ER and impacting signal pathway Related Articles | Metrics