Journal of International Reproductive Health/Family Planning ›› 2012, Vol. 31 ›› Issue (6): 462-466.

• 综述 • Previous Articles     Next Articles

The Multifetal Reduction Technology and Its Influence on Mother and Fetus

TAN Wen-ya,CHEN Lei-ning,QUAN Song   

  1. Reproductive Medical Center,Department of Obstetrics and Gynecology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-11-15 Online:2012-11-15
  • Contact: QUAN Song

Abstract: The incidence of iatrogenic multifetal pregnancy was significantly increased as the development of assisted reproductive technology. Multifetal pregnancy increased the risk of premature delivery,miscarriage,low birth weight,twin transfusion syndrome and premature rupture of membranes. Those adverse events seriously affected the maternal-fetal outcome. Fetal reduction as an important remedial measures to control multiple pregnancy has been widely used to reduce complications and risks of maternal and child. This article reviewed the timing,means,methods,and impact on maternal and child of the multifetal reduction in recent years. Generally,the multifetal reduction operation was done via vagin in early gestation (7~8 weeks),while the selective multifetal reduction operation in 12~14 weeks. Transvaginal aspiration of embryo may be the most effective and safe. However,the operation itself may cause uncertain damage. Therefore,it is necessary to improve techniques of embryos culture,cryopreservation and thawing as well as embryo selection,and to choose the best transplantation timing,to reduce the occurrence of multiple pregnancy. At present,the selective single embryo transplantation was advocated.