Abstract: Objective: To analyze the influence of pregnancy combined with syphilis on perinatal outcomes，and to explore the clinical significance of standard treatment to improve the perinatal outcomes and the perinatal infant prognosis. Methods：This clinical analysis was based on 79 cases of pregnant syphilis diagnosed in our Department among Dec. 2009 and Dec. 2012. According to the treatment condition of pregnancy syphilis，79 cases were divided into three groups：the full course treatment group （Group A，32 cases），the none-full course treatment group （Group B，30 cases） and the none treatment group （Group C，17 cases）. The pregnancy outcomes，perinatal infant prognosis，and the case of congenital syphilis，were compared among three groups. Results：There was statistical significance in the term birth rate among three groups （P＜0.05）. The term birth rate in Group A was 93.8%，which was higher than those in Group B （80.0%，but P＞0.05） and Group C （58.8%，P＜0.05）. The cases of congenital syphilis in three groups were 6，9 and 17，respectively，with the statistical significance in the occurrence rate （P＜0.05）. The cases of pre-term birth in three groups were 2，4 and 4，respectively，without statistical significance in the occurrence rate （P＞0.05）. The cases of still birth in three groups were 0，1 and 1，respectively，without statistical significance in the occurrence rate（P＞0.05）. Conclusions：It is suggested that syphilis should be screened during pregnancy by the serological test. Early detection and standard treatment of syphilis are of two keys to improve the perinatal outcomes and to reduce the rate of congenital syphilis.

Key words: Pregnancy, Syphilis, Pregnancy outcome, Therapy