Abstract: Orphan nuclear receptor NR4A1, a member of the nuclear receptor superfamily， is widely expressed in different cell types. NR4A1 mediates diverse biological processes， such as cell cycle（proliferation or apoptosis）， formation of steroid hormoｎｅ and is involved， NR4A1 was closely related with neurological diseases， ｔｕｍｏｒ， ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ. Recently， emerging evidence suggested that NR4A1 played an important role in ｔｈｅ ｔｒａｎｓｃｒｉｐｔｉｏｎａｌ ｒｅｇｕｌａｔｉｏｎ ｏｆ ｅｎｅｒｇｙ ｍｅｔａｂｏｌｉｓｍ and ｂａｌａｎｃｅ.