Journal of International Reproductive Health/Family Planning

Journal of International Reproductive Health/Family Planning ›› 2010, Vol. 29 ›› Issue (2): 69-71.

• 论著 • Previous Articles     Next Articles

The Research of the Relationship Between the CREM Gene Mutation and the IdiopathicSpermatogenesis Impairment

WANG Jiong, JIA Shu-hua, CHEN Yun-xia, WU Yan-jun, MIAO Cong-xiu,
WANG Gai-qin   

  1. Department of gynecology and obstetrics, Heji Hospital, Changzhi Medical College, Changzhi 046011, China（WANG Jiong）; Histology and Embryology Teaching and Research, Changzhi Medical College, Changzhi 046000, China （JIA Shu-hua, WANG Gai-qin）; Immunology Teaching and Research, Changzhi Medical College, Changzhi 046000, China（CHEN Yun-xia，WU Yan-jun）; Reproductive Genetics Center, Heping Hospital,Changzhi Medical College, Changzhi 046000, China（MIAO Cong-xiu）
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-03-15 Online:2010-03-15

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Abstract:

Objective：To research the relationship between the cyclic AMP-responsive element modulator (CREM) gene mutation and the idiopathic permatogenesis impairment in male infertility. Methods：The peripheral bloods were collected from 20 patients with azoospermia and 20 patients with serious oligospermia. The peripheral bloods of 20 volunteers with normal fertility were collected as control group. The CREM gene of patients with the idiopathic spermatogenesis impairment was detected by collecting the DNA of
the peripheral blood, PCR amplification and single-strand conformation polymorphism. Results：65% of the patients with azoospermia and 55% of the patients with serious oligospermia had the CREM gene mutation. Conclusion：CREM gene plays an important role in the process of sperm development for humans. CREM gene is involved in human spermatogenesis occurrence.

Key words: Cyclic AMP-responsive element moclulator gene, Idiopathic spermatogenesisimpairment, Male infertility