Abstract: The infertility is a serious negative life event for couples. Although in vitro fertilization-embryo transfer（IVF-ET） and its derivative technology bring hope to those couples，the pain during treatment，the worry for outcome and the financial burden also increase their psychological stress. The psychological stress impacts the treating procedure and outcome of IVF-ET/ICSI，suggesting that doctors of reproductive medicine and psychological medicine should pay more attention to this issue. In this article, we reviewed the effect of psychological factors on the clinical outcomes of IVF-ET/ICSI treatment，as well as the potential neurobiological mechanism. We also imparted some new consideration and advice on psychological intervention.

Key words: Fertilization in vitro, Embryo transfer, Infertility, Treatment outcome, Psychology