The Impact of Vitamin D on Assisted Reproductive Technology Outcomes in Women with Polycystic Ovary Syndrome

doi:10.12280/gjszjk.20250274

Abstract

Abstract:

Polycystic ovary syndrome (PCOS), a prevalent endocrine and metabolic disorder among women of reproductive age, is one of the primary causes of female infertility. Recent studies have demonstrated that the level of vitamin D (VD) was correlated with the clinical characteristics and pathogenesis of PCOS, influencing reproductive function and outcomes of assisted reproductive technology (ART). VD may improve ART outcomes through multiple mechanisms: by regulating the hypothalamic-pituitary-ovarian axis to improve insulin resistance and hyperandrogenemia, thereby optimizing follicular development and ovulation; and by modulating the endometrial microenvironment via key receptivity genes and uterine adipokines to support embryo implantation. However, its impact on ART outcomes of PCOS women remains controversial, with the indeterminacy in optimal dosage, route and safety. Future large-scale, high-quality randomized controlled trials are needed to clarify its effects on pregnancy outcomes and establish standardized supplementation strategies.

Key words: Polycystic ovary syndrome, Infertility, female, Vitamin D, Reproductive techniques, assisted, Pregnancy outcome

KONG Jing, YU Lan, ZHANG Cui-lian. The Impact of Vitamin D on Assisted Reproductive Technology Outcomes in Women with Polycystic Ovary Syndrome[J]. Journal of International Reproductive Health/Family Planning, 2026, 45(2): 154-159.

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