Abstract: Objective: to investigate the relationship between glucose metabolism and GADA in PCOS patients. Methods: Seventy-three PCOS patients who attended to our center from 2009-5 to 2009-10 are divided into 2 groups: group A has 35 patients whose glucose tolerance test are normal while group B has 38 patients whose glucose tolerance test are abnormal. The same 73 patients are divided again according to the GADA test: group C has 27 patients who are GADA positive while group D has 46 patients who are GADA negative. The differences of age, BMI, endocrine test, glucose and insulin releasing test and GADA results between group A, B and group C, D were compared. Results: Twenty-seven patients are the GADA positive and the positive rate is 36.9%. The BMI, FPG, 2h glucose and insulin releasing test in group B are higher than those in group A. Fasting insulin and GADA test in group B are higher than those in group A which showed no statistical differences. There are no differences of age, infertile time and endocrine test between group A, B and group C, D. Conclusion: Further research is needed to illustrate the relationship between PCOS and LADA even though the GADA is an effective index to diagnose the LADA.

Key words: PCOS, LADA, GADA