Abstract: Protein kinase C（PKC），as a multifunctional serine/threonine protein kinase and important
component of cell signaling pathways，takes part in many physiological processes in regulating cell cycle，
growth，proliferation，differentiation and apoptosis. It has been proved that isozymes of PKC are expressed in
sperm and oocyte and can participate in fertilization，therefore further understanding has been showed that the
physiological role of PKC would be imperative in exploring molecular mechanism of asthenospermia，oocyte
maturation and fertilization.

Key words: Protein kinase C, Sperm motility, Oocyte, Fertilization, Asthenozoospermia