Abstract: Fetal aneuploidy is the most common cause for Recurrent Pregnancy Loss (RPL). However， the next pregnancy prognosis among women with PRL are usually better than women with sporadic losses, the value of fetal karyotype from couples experiencing two or more losses becomes doubtful. This article reviews the incidence rate of fetal abnormal chromosome in PRL, analysis the mechanism and influence factors behind this phenomenon. Discuss the benefits and development about this technique can bring during the process of treatment in PRL.

Key words: RPL, fetal chromosome testing, PGS