国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2010, Vol. 29 ›› Issue (2): 102-104.

• 综述 • 上一篇    下一篇

生长分化因子-9 与卵泡发育和卵巢早衰

李爽;柴淑娟;夏天;夏阳   

  1. 300193 天津中医药大学（李爽，柴淑娟）;天津中医药大学第一附属医院（夏天，夏阳）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-03-15 发布日期:2010-03-15

Research Progress on Growth Differentiation Factor鄄9, Follicular Development and Premature OvarianFailure

LI Shuang;CHAI Shu-juan;XIA Tian;XIA Yang   

  1. Tianjin University of TCM，the First ClinicalMedical College Affiliated to Tianjin University of TCM，Tianjin 300193，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-03-15 Online:2010-03-15

PDF (PC)

7136

摘要： 生长分化因子-9是重要的卵母细胞源性生长因子。其在促进卵母细胞生长与分化以及颗粒细胞增殖、卵丘膨胀、抑制颗粒细胞和卵泡膜细胞分化的过程中起重要作用。卵巢早衰是病因不清又无有效治疗手段的复杂疾病。研究认为，卵巢内始基卵泡形成数目的减少、已形成的卵泡闭锁速度加快和对促性腺激素刺激不敏感是造成卵巢早衰的主要病因。生长分化因子-9参与了这一过程。

关键词: 生长分化因子-9, 卵泡发育, 卵巢早衰

Abstract: Growth differentiation factor-9 is an important oocyte-derived growth factor. It plays an
important role in the process of promoting oocyte growth and differentiation，granulose cell proliferation，
cumulus expansion and inhibitting granulose cell and follicular membrane cell differentiation. Premature
ovarian failure is a complex disease that has no clear pathogenesis and effective treatment methods. Present
studies show that the reduction of follicular number，the acceleration of follicular depletion and the insensitive
to the follicular stimulating hormone are the primary causes of the premature ovarian failure. Growth
differentiation factor-9 participates in these processes.

Key words: Growth differentiation factor-9, Follicular development, Premature ovarian failure