国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2011, Vol. 30 ›› Issue (3): 159-163.

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神经管畸形相关磷脂代谢的研究进展

黄 敏, 梁琼麟, 王义明, 胡 坪, 罗国安   

  1. 200237 上海，华东理工大学药学院（黄 敏，罗国安）；清华大学化学系（黄 敏，梁琼麟，王义明）；华东理工大学化学与分子工程学院（胡 坪）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-05-15 发布日期:2011-05-15
  • 通讯作者: 罗国安

Research Progress of Neural Tube Defects Related Phospholipids Metabolism

HUANG Min， LIANG Qiong-lin， WANG Yi-ming， HU Ping， LUO Guo-an   

  1. School of Pharmacy， East China University of Science and Technology， Shanghai 200237， China（HUANG Min， LUO Guo-an）； Department of Chemistry， Tsinghua University， Beijing 100084， China（HUANG Min， LIANG Qiong-lin， WANG Yi-ming）； School of Chemistry and Molecular Engineering， East China University of Science and Technology， Shanghai 200237， China（HU Ping）
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-05-15 Online:2011-05-15
  • Contact: LUO Guo-an

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摘要： 神经管畸形是一种复杂严重的先天性中枢神经系统畸形，最常见的表现为无脑和脊柱裂。神经管的发育与基因、环境等许多因素有关，其中母体的营养情况包括维生素B12、同型半胱氨酸、叶酸及胆碱等与之密切相关，但是与叶酸、胆碱、同型半胱氨酸代谢均有联系的磷脂相关代谢的报道却很少。综述磷脂代谢、脂质介质及相关反应酶在神经管畸形发生发展中的作用及研究现状。

关键词: 神经管畸形, 磷脂, 胆碱, 脂质介质, 叶酸

Abstract: Neural tube defects are complex and severe congenital malformations of central neural system with high incidence. Anencephaly and spina bifida are the most common and severe forms of NTD. Failure of the primary embryonic neural tube to close or secondarily reopening is direct reasons leading to NTD. Development of the neural tube is related to lots of genes and environmental factors， in which maternal nutrition situation is one of the most important reported in many literatures， including vitamin B12，homocysteine， folic acid and choline， etc. However， phospholipids metabolism related to folic acid， choline and homocysteine metabolisms was rarely mentioned. Herein， this paper reviewed the role of phospholipids metabolism， lipid mediators and enzymes in generation and development in neural tube defects and its research status.

Key words: Neural tube defects, Phospholipids, Choline, Lipid mediator, Folic acid