国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2011, Vol. 30 ›› Issue (3): 258-261.

• 综述 • 上一篇    下一篇

BMI-1基因在妇科肿瘤中的研究进展

高 翔, 张淑兰   

  1. 110004 沈阳，中国医科大学附属盛京医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-05-15 发布日期:2011-05-15

Research Progress of BMI-1 in Gynecological Tumors

GAO Xiang, ZHANG Shu-lan   

  1. Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical Uuniversity, Shenyang 110004, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-05-15 Online:2011-05-15

PDF (PC)

7302

摘要： B细胞特异的莫洛尼白血病毒插入位点1基因（B?鄄cell specific moloney murine leukemiavirus insertion site 1， BMI-1）是多疏基因（polycomb group gene）家族重要的调节基因，被认为是癌基因。BMI-1在调节干细胞自我更新、细胞增殖和衰老中发挥重要作用。近年研究发现，BMI-1在多种肿瘤中表达异常，如乳腺癌、肝癌和鼻咽癌等，其不仅与肿瘤的发生、发展密切相关，而且在肿瘤的诊断、病情评估和预后等方面发挥着重要作用。目前，关于BMI-1在妇科肿瘤中的研究尚少，但现有研究证实其与妇科肿瘤的发生发展显著相关。随着对该基因深入研究，其在妇科肿瘤的诊断、治疗、预后等方面将发挥重要的作用。

关键词: B细胞特异的莫洛尼白血病毒插入位点1基因, 生殖器肿瘤, 女（雌）性, 癌基因, 基因表达, 诊断

Abstract: B-cell specific moloney leukemia virus insertion site 1（BMI-1） gene, as an oncogene, is a regulating gene of polycomb group（PcG） gene family. BMI-1 plays an important role in proliferation of stem cell, cellular self-renew and ageing. In recent years, it was found that BMI-1 expressed abnormally in a wide variety of tumors, such as breast cancer, liver cancer and nasopharyngeal darcinoma, BMI-1 is closely related to the occurrence and development of tumor, so it can be used in diagnosis, assessment and prognosis of tumors. At present, study of BMI-1 in gynecologic oncologists was less, but it has been shown that BMI-1 was closely related to the development of gynecological cancer. We believed that BMI-1 would be a candidate factor for the diagnosis, treatment and prognosis of gynecological tumors.

Key words: BMI-1, Genital neoplasms, female, Oncogenes, Gene expression, Diagnosis