国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2012, Vol. 31 ›› Issue (2): 115-118.

• 综述 • 上一篇    下一篇

FISH在罗伯逊易位携带者胚胎植入前遗传学诊断中的应用

鲁琳琳,白晓红   

  1. 300052天津医科大学总医院生殖医学中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-03-15 发布日期:2012-03-15
  • 通讯作者: 白晓红

The Clinical Application of Fluorescence in Situ Hybridization for Preimplantation Genetic Diagnosis of Robertsonian Translocation Carriers

LU Lin-lin, BAI Xiao -hong   

  1. Reproductive Medicine Center,Tianjin Medical University General Hospital, Tianjin 300052, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-03-15 Online:2012-03-15
  • Contact: BAI Xiao-hong

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摘要： 胚胎植入前遗传学诊断（PGD）是辅助生殖技术中的一种重要手段，染色体异常的诊断是植
入前遗传学诊断的一个重要部分。利用荧光原位杂交（FISH）技术对罗伯逊易位携带者体外受精的胚胎行植入
前遗传学诊断，可解决生育问题、减少遗传风险，达到优生目的。综述荧光原位杂交技术及近年来该技术
在罗伯逊易位携带者胚胎植入前遗传学诊断中的应用。

关键词: 原位杂交, 荧光, 易位, 遗传, 胚胎植入, 植入前诊断, 生殖技术, 辅助

Abstract: Preimplantation genetic diagnosis (PGD) is an important technology of the assisted reproductive technology (ART). The diagnosis of chromosomal abnormality is an important part of PGD. For thein vitro fertilization embryos of Robertsonian translocation carriers，fluorescence in situ hybridization (FISH) asa PGD technology can be used to solve the fertility problem, to reduce genetic risk and achieve the eugenicpurposes. This review summarized current knowledge of FISH and its application in PGD of the Robertsoniantranslocation carriers.

Key words: In situ hybridization, fluorescence, Translocation, genetic, Embryo implantation, Preimplantation diagnosis, Reproductive techniques, assisted