国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2013, Vol. 32 ›› Issue (3): 211-213.

• 综述 • 上一篇    下一篇

肿瘤坏死因子凋亡微弱诱导剂与妇科肿瘤的研究进展

马 宁, 邱丽华   

  1. 200001 上海交通大学医学院附属仁济医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-05-15 发布日期:2013-05-15
  • 通讯作者: 邱丽华

Tumor Necrosis Factor-like Weak Inducer of Apoptosis and Gynecologic Neoplasms

MA Ning，QIU Li-hua   

  1. Department of Gynecology and Obstetrics，Renji Hospital，School of Medicine，Shanghai Jiaotong University，Shanghai 200001，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-05-15 Online:2013-05-15
  • Contact: QIU Li-hua

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摘要： 肿瘤坏死因子凋亡微弱诱导剂（tumor necrosis factor-like weak inducer of apoptosis，TWEAK）是新发现的肿瘤坏死因子超家族成员，广泛表达于人体各种组织细胞中，通过与其受体成纤维细胞生长诱导因子14（fibroblast growth factor-inducible 14，Fn14）特异性结合发挥生物学效应。TWEAK和Fn14在肿瘤的发生发展中起重要的调控作用，包括诱导细胞凋亡，促进细胞增殖和血管形成，提高细胞侵袭力和炎症效应等。最新研究认为，TWEAK和Fn14与妇科肿瘤的发生发展密切相关，可能成为妇科肿瘤治疗的新靶点。

关键词: 生殖器肿瘤, 女（雌）性, 肿瘤坏死因子类, TNF相关凋亡诱导配体, 肿瘤坏死因子凋亡微弱诱导剂, 成纤维细胞生长诱导因子14

Abstract: Tumor necrosis factor-like weak inducer of apoptosis （TWEAK） is a new member of the TNF family, which widely expressed in human tissues. TWEAK plays biological roles by combining specifically its receptor, fibroblast growth factor-inducible 14 （Ｆｎ１４）. TWEAK -Fn14 system is important in regulating tumor development and prognosis, including cell apoptosis, tumor hyperplasia, differentiation, angiopoiesis, invasion and inflammation. It was demonstated that the TWEAK -Fn14 signaling was related to gynecologic tumors, and that TWEAK -Fn14 maybe a potential candidate target for treatment of gynecologic neoplasms.

Key words: Genital neoplasms, female, Tumor necrosis factors, TNF-related apoptosis-inducing ligand, Tumor necrosis factor-like weak inducer of apoptosis, Fibroblast growth factor-inducible 14