全氟化合物对女性生殖健康及辅助生殖技术结局的影响

doi:10.12280/gjszjk.20250287

摘要/Abstract

摘要：

全氟化合物（per- and polyfluoroalkyl substances，PFAS）存在于多种场所和消费品中，经过呼吸、饮食、皮肤接触等途径进入人体，对女性生殖健康造成不良后果。研究表明，PFAS可以通过干扰内分泌轴、损害线粒体功能、诱导氧化应激、破坏缝隙连接通讯及调控表观遗传等途径影响卵巢功能，从而产生生殖毒性，与多囊卵巢综合征、早发性卵巢功能不全、卵巢储备功能减退和子宫内膜异位症等女性生殖系统疾病存在一定关联。在接受辅助生殖技术（assisted reproductive technology, ART）治疗的不孕人群中发现，PFAS水平与获卵数、双原核数和胚胎质量等呈负相关，对ART助孕结局造成负面影响。综述PFAS对女性生殖健康及ART结局的影响，以期为后续研究提供依据。

关键词: 氟化合物, 生殖健康, 生殖技术，辅助, 卵巢, 女（雌）性泌尿生殖系统疾病

Abstract:

Per- and polyfluoroalkyl substances (PFAS) exist in life area and consumer products, and enter the human body through breathing, diet, skin contact and other ways. PFASs cause the adverse consequence to female reproductive health. Studies have shown that PFAS can affect ovarian function by interfering with the endocrine axis, damaging mitochondria, inducing oxidative stress, disrupting gap junction communication, and regulating epigenetics, and resulting in reproductive toxicity, which is also related to many diseases of female reproductive system such as polycystic ovary syndrome, premature ovarian insufficiency, diminished ovarian reserve and endometriosis. In infertile people treated with assisted reproductive technology (ART), it was also found that the level of PFAS was negatively correlated with oocyte yield, the number of two pronuclei, and embryo quality, adversely affecting ART outcomes. We review the impact of PFAS on female reproductive health and ART outcomes, in order to provide a new evidence for the subsequent research.

Key words: Fluorine compounds, Reproductive health, Reproductive techniques, assisted, Ovary, Female urogenital diseases

熊敏, 杨丹丹, 柴梦晗, 张倩楠, 章志国, 陈蓓丽. 全氟化合物对女性生殖健康及辅助生殖技术结局的影响[J]. 国际生殖健康/计划生育杂志, 2025, 44(5): 411-415.

XIONG Min, YANG Dan-dan, CHAI Meng-han, ZHANG Qian-nan, ZHANG Zhi-guo, CHEN Bei-li. Effects of Per- and Polyfluoroalkyl Substances on Female Reproductive Health and Outcomes of Assisted Reproductive Technology[J]. Journal of International Reproductive Health/Family Planning, 2025, 44(5): 411-415.

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