国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2013, Vol. 32 ›› Issue (6): 502-505.

• 综述 • 上一篇    下一篇

胚胎干细胞向子宫内膜样细胞分化中Wnt信号通路的调控作用

于文竹,孙莹璞   

  1. 450052 郑州大学第一附属医院生殖医学中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-11-15 发布日期:2013-11-15
  • 通讯作者: 孙莹璞

Regulation of the Wnt Signaling Pathway on the Differentiation of Endometrial-like Cells from Embryonic Stem Cells

YU Wen-zhu，SUN Ying-pu   

  1. Reproductive Medicine Center，First Affiliated Hospital of Zhengzhou University，Zhengzhou 450052，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-11-15 Online:2013-11-15
  • Contact: SUN Ying-pu

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摘要： 人胚胎干细胞是人体内最原始的细胞，具有自我更新和分化为各种细胞的潜能，而信号通路在细胞的形态和功能变化中起着重要的协调和控制作用。目前的研究已经证实，Wnt信号通路在女性生殖系统的发育中起着重要的作用，是其分化形成的关键因子，在胚胎干细胞定向分化为子宫内膜样细胞的过程中，Wnt信号通路同样起着关键的调控作用。综述Wnt信号通路在人胚胎干细胞向子宫内膜样细胞分化过程中所起的作用，并展望今后对其的研究方向。

关键词: 胚胎干细胞, Wnt蛋白质类, 子宫内膜, 细胞分化, 基因调控网络

Abstract: Human embryonic stem cells（hESCs） are the most primitive cells with the potential for self-renewal and differentiation of various cell. The signaling pathways play important roles in regulating cellular morphology and function. Present study confirmed that the Wnt signaling pathway, as one of the key factors of differentiation, played an important role in regulating the development of female reproductive system. This pathway plays same key role during the differentiation of endometrial-like cells from embryonic stem cell. This review is about the Wnt signaling pathway in hESCs differentiation to endometrial cells，and the future research.

Key words: Embryonic stem cells, Wnt proteins, Endometrium, Cell differentiation, Gene regulatory networks