国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2014, Vol. 33 ›› Issue (6): 469-474.

• 论著 • 上一篇    下一篇

曼月乐与热球子宫内膜去除术治疗月经过多疗效的Meta分析

蒋志峰，陈昌益，冯力民   

  1. 530021南宁，广西壮族自治区人民医院妇科（蒋志峰，陈昌益）；首都医科大学附属北京天坛医院妇产科（冯力民）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-11-15 发布日期:2014-11-15
  • 通讯作者: 陈昌益

Clinical Efficacy of Mirena Comparing with Thermal Balloon Endometrial Abliation for Menorrhagia：a Meta-Analysis

JIANG Zhi-feng，CHEN Chang-yi，FENG Li-min   

  1. Department of Gynecology，The People′s Hospital of Guangxi Zhuang Autonomous Region，Nanning 530021，China（JIANG Zhi-feng，CHEN Chang-yi）；Department of Obstetrics and Gynecology，Beijing Tian Tan Hospital，Capital Medical University，Beijing 100050，China（FENG Li-min）
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-11-15 Online:2014-11-15
  • Contact: CHEN Chang-yi

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摘要： 目的：探讨左炔诺孕酮宫内缓释系统（商品名曼月乐，Mirena）和热球子宫内膜去除术治疗女性月经过多的临床疗效。方法：检索国内外知名数据库，纳入曼月乐和热球子宫内膜去除术治疗月经过多的随机对照试验，对所纳入文献的质量进行方法学评价，并使用RevMan 5.2 软件进行统计分析。结果：两种治疗方法治疗12个月后，有效率、失败率及患者满意度差异均无统计学意义（P＞0.05），曼月乐组术后并发症发生率和直接医疗成本低于热球子宫内膜去除术，差异有统计学意义（P＜0.05）。结论：曼月乐对月经过多的治疗安全有效，与传统的热球子宫内膜去除术相比是一种较好的保守性治疗手段。

关键词: 月经过多, 左炔诺孕酮, 迟效制剂, 宫内避孕器, 含药, 子宫内膜, Meta分析

Abstract: Objective：To compare the clinical efficacy of Mirena with the thermal balloon endometrial ablation for menorrhagia treatment. Methods： The well-known databases in both English and Chinese were retrieved. The randomized controlled trials of Mirena and the thermal balloon endometrial ablation were included after evaluating the quality of methodology. Revman 5.2 software was then used to do statistics. Results：There were not statistical differences in the effective rate, the failure rate and the patient satisfaction between two methods. The incidence of postoperative complications and the direct medical cost in the Mirena group were significantly lower than those in the thermal balloon endometrial ablation group （P＜0.05）. Conclusions：Mirena is safe and effective for patients with menorrhagia. Compared with the thermal balloon endometrial ablation, Mirena is a better alternative method as the conservative treatment for menorrhagia.

Key words: Menorrhagia, Levonorgestrel, Delayed-action preparations, Intrauterine devices, medicated, Endometrium, Meta-analysis