国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2020, Vol. 39 ›› Issue (4): 269-275.

• 论著 •    下一篇

我国围生儿先天性心脏病发病率的Meta分析

许文婧，魏莉莉，王莹，魏颖，王剑，毛宝宏，陶仲宾，杨克虎，刘青   

  1. 730000  兰州，甘肃中医药大学（许文婧，王莹，魏颖）；兰州大学第二医院（魏莉莉）；甘肃省妇幼保健院（许文婧，魏颖，王剑，毛宝宏，刘青）；兰州大学第一医院小儿科（陶仲宾）；兰州大学基础医学院循证医学中心（杨克虎）
  • 收稿日期:2020-03-05 修回日期:2020-04-11 出版日期:2020-07-15 发布日期:2020-07-15
  • 通讯作者: 杨克虎，E-mail：yangkh2006@163.com；刘青，E-mail：2305410816@qq.com E-mail:498107946@qq.com
  • 基金资助:
    甘肃省自然科学基金项目（18JR3RA032）

Incidence of Perinatal Congenital Heart Disease in China：A Meta-Analysis

XU Wen-jing，WEI Li-li，WANG Ying，WEI Ying，WANG Jian，MAO Bao-hong，TAO Zhong-bin，YANG Ke-hu，LIU Qing   

  1. Gansu University of Chinese Medicine，Lanzhou 730000，China（XU Wen-jing，WANG Ying，WEI Ying）；The Second Hospital Affiliated to Lanzhou University，Lanzhou 730030，China（WEI Li-li）；Gansu Provincial Maternal and Child Care Hospital，Lanzhou 730050，China（XU Wen-jing，WEI Ying，WANG Jian，MAO Bao-hong，LIU Qing）；Department of Paediatrics Medicine，The First Hospital of Lanzhou University，Lanzhou 730030，China（TAO Zhong-bin）；Evidence-Based Medicine Center of Basic Medical Science，Lanzhou University，Lanzhou 730030，China（YANG Ke-hu）
  • Received:2020-03-05 Revised:2020-04-11 Published:2020-07-15 Online:2020-07-15
  • Contact: YANG Ke-hu，E-mail：yangkh2006@163.com；LIU Qing，E-mail：2305410816@qq.com E-mail:498107946@qq.com

PDF (PC)

11468

摘要：
【摘 要】 目的：系统评价我国围生儿先天性心脏病（CHD）的发病情况。方法：通过计算机对中英文数据库进行检索，搜集关于我国围生儿CHD发病率的相关研究，检索时间从建库起至2020年1月。由2位研究人员独立筛选文献、提取数据，并对纳入研究质量进行评价，研究结果采用Stata 12.0进行Meta分析。结果：共纳入29篇原始文献，涵盖8 327 724名研究对象。Meta分析结果显示：我国围生儿CHD发病率为2.9‰（95%CI：2.2‰～3.8‰）。亚组分析显示，室间隔缺损为CHD的主要表现亚型；男性围生儿的CHD发病率（2.9‰）高于女性（2.2‰）；城市围生儿CHD发病率（2.5‰）高于农村（1.1‰）；南方围生儿CHD发病率（3.5‰）高于北方（2.1‰）；母亲年龄≥35岁者围生儿CHD发病率（2.8‰）高于母亲年龄＜35岁者（2.0‰）；围生儿CHD发病率在2007—2012年出现下降，随后呈现上升趋势。结论：我国围生儿CHD的发病率呈上升趋势。应采取更有目的性和针对性的干预措施，以期降低CHD的发生率。

关键词: 心脏缺损, 先天性；, 发病率；, 中国；, 孕妇；, Meta分析

Abstract: Objective: To evaluate the incidence of congenital heart disease (CHD) among perinatal kids in China. Methods：English and Chinese databases were electronically searched, to get the studies on the prevalence of COH in China from the creation of databases to January 2020. Two investigators independently reviewed those included studies, extracted data and evaluated data quality. Stata 12.0 software was used for the meta-synthesis. Results：29 original literatures were screened, reporting 8 327 724 subjects. Meta-regression analyses revealed that the total incidence of CHD among perinatal kids of China was 2.9‰ (95%CI: 2.2‰-3.8‰). The subgrouped analysis showed that ventricular septal defect was the main subtype. The incidence of CHD in male perinatal kids (2.9‰) was higher than that in female perinatal kids (2.2‰). The incidence of perinatal CHD in urban (2.5‰) was higher than that in rural (1.1‰). This incidence in the south (3.5‰) was higher than that in the north (2.1‰). The incidence of perinatal CHD of maternal age ≥35 (2.8‰) was higher than that of maternal age ＜35 (2.0‰). This incidence decreased from 2007 to 2012, and then showed an increasing trend from 2012. Conclusions：The ncidence of COH among perinatal kids of China showed an increasing trend in recent years. More targeted interventions should be provided so as to reduce the incidence of CHD.

Key words: Heart disease, congenital；, Incidence；, China；, Pregnant women；, Meta-analysis