国际生殖健康/计划生育 ›› 2017, Vol. 36 ›› Issue (4): 345-348.

• 综述 • 上一篇    下一篇

大气污染物与妊娠期高血压疾病的关系

马世月,侯海燕,陈亚琼   

  1. 300193  天津中医药大学(马世月);中国人民武装警察部队后勤学院附属医院妇产科(侯海燕、陈亚琼);中国医学科学院北京协和医学院(侯海燕)
  • 收稿日期:2017-04-24 修回日期:2017-06-11 出版日期:2017-07-15 发布日期:2017-07-15
  • 通讯作者: 陈亚琼,E-mail:chenyq82@hotmail.com E-mail:chenyq82@hotmail.com
  • 基金资助:
    国家自然科学基金(81528020);天津市自然科学基金(15JCZDJC36000)

Air Pollutants and Hypertensive Disorder Complicating Pregnancy

MA Shi-yue,HOU Hai-yan,CHEN Ya-qiong   

  1. Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China(MA Shi-yue);Department of Obstetrics and Gynecology,Affiliated Hospital of Logistics University of Chinese People's Armed Police Forces,Tianjin 300162,China(HOU Hai-yan,CHEN Ya-qiong);Peking Union Medical College Hospital,China Academy of Sciences,Beijing 100730,China(HOU Hai-yan)
  • Received:2017-04-24 Revised:2017-06-11 Published:2017-07-15 Online:2017-07-15
  • Contact: CHEN Ya-qiong,E-mail:chenyq82@hotmail.com E-mail:chenyq82@hotmail.com

摘要: 雾霾是一种严重的大气污染形式,主要由气态污染物和颗粒物组成。颗粒物理化特性强,危害性大,是加重雾霾天气污染的重要原因。妊娠期高血压疾病(HDP)是一种较为常见的严重危害母婴健康的妊娠期特有疾病,其病因及发病机制尚不明确。妊娠期妇女的生理特性使孕妇和胎儿对污染物的易感性增加。现有研究证实,HDP与妊娠期孕妇大气污染物的暴露关系密切,发生机制主要与大气污染物激活机体氧化应激反应和系统性炎症有关,其具体致病机制有待进一步研究。现就雾霾与妊娠期高血压、子痫前期之间的相关性进行综述。

关键词: 空气污染, 颗粒物, 高血压, 妊娠性, 雾霾, 气态污染物

Abstract: Haze, a serious form of air pollution, is mainly consists of gaseous pollutants and particulate matter. With high physicochemical properties and great harmfulness, particulate matter is the key point of haze. Hypertensive disorders of pregnancy (HDP) is a common clinical disease specially correlated to pregnancy, which had serious harm on maternal and child health. The etiology and pathogenesis mechanism of HDP is not yet entirely clear. The physiological characteristics of pregnant women make them and fetus to be susceptible to pollutants and to increase their exposure to air pollutants. Previous studies confirmed the close relations between HDP and maternal exposure to air pollutants during pregnancy. The pathogenesis might be related with oxidative stress and systemic inflammation. However, those hypothese need more study to validate. In this paper, we discuss the close relations between haze and gestational hypertension and preeclampsia.

Key words: Air pollution, Particulate matter, Hypertension, pregnancy-induced, Haze, Gaseous pollutants