环状RNA与妊娠相关疾病

doi:10.12280/gjszjk.20220227

摘要/Abstract

摘要：

环状RNA（circular RNA,circRNA）由反向剪接的信使RNA前体产生的非编码RNA组成,在反向剪接过程中,下游剪接供体位点与上游剪接受体位点共价连接。circRNA广泛存在于各类真核生物细胞和有机体中,结构稳定。随着高通量测序等分子生物技术的快速发展,circRNA的生物学作用得以被认识,并成为生物学研究领域的新方向。近年研究表明,正常妊娠与病理妊娠相比较,在其胎盘组织及母体血浆中circRNA的表达存在显著差异,circRNA通过调控滋养细胞上皮间质转化、胎盘微血管形成、妊娠期葡萄糖和脂质代谢稳态和介导母胎界面炎症微环境等过程,影响妊娠期疾病的发生发展。circRNA与微小RNA、RNA结合蛋白的相互作用也可调节胎盘自噬及母体脂肪代谢。综述circRNA的生物学作用及其在妊娠相关疾病中的研究进展。

关键词: 环状RNA, 流产,习惯性, 先兆子痫, 糖尿病,妊娠, 高血压,妊娠性

Abstract:

Circular RNA (circRNA) is composed of the non-coding RNAs generated by a noncanonical splicing event which called reverse splicing. In reverse splicing, the downstream splicing site is covalently connected to the upstream splicing receptor site. CircRNA with stable structure widely exists in various eukaryotic cells and organisms. With the rapid development of molecular biotechnology such as high-throughput sequencing, the biological role of circRNA has been revealed. CircRNA has become a star in the field of biological research. Studies in recent years have found the different expression of circRNA in the placental tissue and maternal plasma of pathological pregnancy. CircRNA influences the occurrence and development of pregnancy diseases by participating in the regulation of trophoblast epithelial stromal transformation, placental microvasculogenesis, glucose and lipid metabolism homeostasis during pregnancy, and by mediating the microenvironment of maternal and fetal interface inflammation. CircRNA also interacts with miRNA and RNA-binding proteins, in which regulates placental autophagy and maternal fat metabolism. This paper aims to introduce circRNA and its research progress in pregnancy-related diseases.

Key words: Circular RNA, Abortion, habitual, Pre-eclampsia, Diabetes, gestational, Hypertension, pregnancy-induced

高倩倩, 冯晓玲. 环状RNA与妊娠相关疾病[J]. 国际生殖健康/计划生育, 2022, 41(5): 430-435.

GAO Qian-qian, FENG Xiao-ling. CircRNA and Pregnancy-Related Diseases[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(5): 430-435.

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