5-羟色胺与不良妊娠结局的研究进展

doi:10.12280/gjszjk.20240532

摘要/Abstract

摘要：

5-羟色胺（5-hydroxytryptamin，5-HT）作为一种神经递质，通过与其受体相互作用，参与调节情绪、食欲和血液循环，并对维持胎盘功能、卵母细胞成熟及早期胚胎发育发挥重要影响。研究显示，妊娠期5-HT水平的异常与妊娠恶心呕吐、妊娠高血压和妊娠期糖尿病等不良妊娠结局密切相关。妊娠期5-HT₃受体水平过高可增加妊娠恶心呕吐或妊娠剧吐的风险；妊娠期5-HT₁、5-HT₂、5-HT₇受体水平异常则使妊娠高血压及妊娠期糖尿病风险升高。阐述5-HT对上述不良妊娠结局的具体作用机制，以期为未来临床防治不良妊娠结局提供新的思路与方向。

关键词: 血清素, 受体, 血清素, 妊娠剧吐, 高血压, 妊娠性, 糖尿病, 妊娠

Abstract:

5-hydroxytryptamin (5-HT) as a neurotransmitter participates in the regulation of mood, appetite and blood circulation by the interaction with its receptors. 5-HT also plays a significant role in maintaining placental function, oocyte maturation, and early embryonic development. Studies have shown that the abnormal level of 5-HT during pregnancy is closely associated with the adverse pregnancy outcomes such as hyperemesis gravidarum, pregnancy-induced hypertension, and gestational diabetes. The elevated level of the 5-HT₃ receptor during pregnancy can increase the risk of nausea and vomiting of pregnancy or hyperemesis gravidarum. The abnormal levels of 5-HT₁, 5-HT₂, and 5-HT₇ receptors during pregnancy can raise the risk of pregnancy-induced hypertension and gestational diabetes. This article aims to elucidate the specific mechanisms that 5-HT affects the adverse pregnancy outcomes, and to provide new potential insights for the future clinical prevention and treatment of adverse pregnancy outcomes.

Key words: Serotonin, Receptors, serotonin, Hyperemesis gravidarum, Hypertension, pregnancy-induced, Diabetes, gestational

刘悦, 高敬书, 王宇, 冯佳兴, 葛航, 吴效科. 5-羟色胺与不良妊娠结局的研究进展[J]. 国际生殖健康/计划生育杂志, 2025, 44(2): 155-160.

LIU Yue, GAO Jing-shu, WANG Yu, FENG Jia-xing, GE Hang, WU Xiao-ke. Research Progress on 5-Hydroxytryptamin and Adverse Pregnancy Outcomes[J]. Journal of International Reproductive Health/Family Planning, 2025, 44(2): 155-160.

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