精子tsRNA在父系遗传中的作用

doi:10.12280/gjszjk.20210453

摘要/Abstract

摘要：

tsRNA（tRNA-derived small RNA）是来源于成熟转运RNA（transfer RNA,tRNA）或tRNA前体的一种小非编码RNA（small non-coding RNA,sncRNA）。研究表明tsRNA是一种重要的RNA调控因子,有望作为疾病预防、诊断和治疗的生物标志物。不同tsRNA表达可能参与蛋白质合成、信使RNA（messenger RNA,mRNA）的翻译转录以及代谢性疾病等多种疾病的发生、发展,并且在精子成熟与代谢性疾病的代际遗传中也扮演了关键角色。阐述tsRNA的分类和生物学功能,尤其是在雄性生殖即精子成熟过程中的表达以及在父系相关代际遗传中的作用,对子代健康的保护具有重要意义。

关键词: RNA,转移, 精子, 精子成熟, 父系遗传, 营养和代谢性疾病, tsRNA

Abstract:

TsRNA (tRNA-derived small RNA) is a class of small non-coding RNA derived from mature tRNA or pre-tRNA. Evidences show that tsRNA is an important RNA regulatory factor, which is expected to be used as a biomarker for disease prevention, diagnosis and treatment. TsRNAs expressed differently may be involved in protein synthesis, mRNA translation and transcription, and the occurrence and development of various diseases such as metabolic diseases. Moreover, tsRNA plays an important role in sperm maturation and the intergenerational inheritance of metabolic diseases. Explaining the classification of tsRNA and its functions in biology, especially in male reproduction (e.g. sperm maturation), as well as its role in paternal intergenerational inheritance, are important for protecting offspring health.

Key words: RNA,transfer, Spermatozoa, Sperm maturation, Paternal inheritance, Nutritional and metabolic diseases, tRNA-derived small RNA

许钰薇, 李文婧, 茅欣怡, 马梲铫, 丁之德. 精子tsRNA在父系遗传中的作用[J]. 国际生殖健康/计划生育, 2022, 41(1): 37-41.

XU Yu-wei, LI Wen-jing, MAO Xin-yi, MA Zhuo-yao, DING Zhi-de. The Role of Sperm TsRNA in Paternal Inheritance[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(1): 37-41.

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