国际生殖健康/计划生育 ›› 2011, Vol. 30 ›› Issue (5): 401-404.

• 综述 • 上一篇    下一篇

多囊卵巢综合征糖代谢异常与2型糖尿病异同点

张阳阳,徐 阳   

  1. 100034 北京大学第一医院生殖与遗传医学中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-09-15 发布日期:2011-09-15

Differences and Similarities Between Abnormal Glucose Tolerance of PCOS and T2DM

ZHANG Yang-yang, XU Yang   

  1. The Reproductive and Genetic Medical Center of Peking University First Hospital, Beijing 100034, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-09-15 Online:2011-09-15

摘要: 多囊卵巢综合征(PCOS)是女性最常见的内分泌紊乱综合征,是引起生育年龄女性月经紊乱和不孕的主要原因之一。PCOS患者合并糖代谢异常的发生率高,常导致2型糖尿病(T2DM)提前发生,对女性的健康造成威胁。胰岛素抵抗(IR)是PCOS和T2DM共同的病理生理基础,但其在两者中的发生机制、组织特异性等均存在不同。现试探讨其中的异同点,为PCOS患者远期并发症的防治提供理论依据。

关键词: 多囊卵巢综合征, 胰岛素抗药性, 糖尿病, 2型, 代谢疾病

Abstract: Polycystic ovary syndrome(PCOS) is the most common endocrine disorder, leading to paramenia and infertility in women. The incidence of the impaired glucose tolerance is high in PCOS population and it is closely related to type 2 diabetes mellitus(T2DM). Insulin resistance(IR) is the common pathophysiological basis in both PCOS and T2DM, but the pathogenesis and tissue?-speciality of IR are different. It could offer the reliable evidence for preventing long?-term complications of PCOS, to compare abnormal glucose tolerance in PCOS and T2DM.

Key words: Polycystic ovary syndrome, Insulin resistance, Diabetes mellitus, type 2, Metabolic diseases