多囊卵巢综合征病理机制中的颗粒细胞自噬

doi:10.12280/gjszjk.20230483

国际生殖健康/计划生育杂志 ›› 2024, Vol. 43 ›› Issue (2): 150-154.doi: 10.12280/gjszjk.20230483

多囊卵巢综合征病理机制中的颗粒细胞自噬

甄佳, 赵紫渊, 王子璐, 师伟, 徐丽^△()

250000 济南，山东中医药大学第一临床医学院（甄佳，王子璐）; 河北医科大学中西医结合学院（赵紫渊）; 山东中医药大学附属医院妇科（师伟）; 山东中医药大学第二附属医院生殖医学中心（徐丽）

收稿日期:2023-11-25 出版日期:2024-03-15 发布日期:2024-03-22
通讯作者: 徐丽 E-mail:xulisw@126.com
基金资助:
山东省自然科学基金面上项目(ZR2021MH198);山东省中医药科技项目面上项目(2021M186)

Granulosa Cell Autophagy in Pathophysiological Mechanism of Polycystic Ovary Syndrome

ZHEN Jia, ZHAO Zi-yuan, WANG Zi-lu, SHI Wei, XU Li()

The First Clinical Medical College of Shandong University of Traditional Chinese Medicine, Jinan 250000, China (ZHEN Jia, WANG Zi-lu); College of Integrative Medicine, Hebei Medical University, Shijiazhuang 050000, China (ZHAO Zi-yuan); Department of Gynecology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250000, China (SHI Wei); Center for Reproductive Medicine, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250000, China (XU Li)

Received:2023-11-25 Published:2024-03-15 Online:2024-03-22
Contact: XU Li E-mail:xulisw@126.com

摘要/Abstract

摘要：

多囊卵巢综合征（polycystic ovary syndrome，PCOS）是育龄期女性最常见的生殖内分泌紊乱性疾病之一，病理机制尚未阐明。自噬参与卵泡发育的各个阶段，其中卵泡颗粒细胞自噬相对活跃。通过维持颗粒细胞自噬的稳态支持卵巢功能、调控卵泡发育，最终影响胚胎质量及妊娠结局。自噬相关基因和蛋白的异常表达可激活不同的自噬通路，抑制卵泡颗粒细胞发育、干扰内分泌稳态，参与PCOS的病理过程，并影响其预后。综述参与颗粒细胞自噬的关键分子及其在PCOS发生发展中的作用，以期为研究PCOS发生机制及探索临床治疗提供参考。

关键词: 多囊卵巢综合征, 卵泡, 自噬, 自噬相关蛋白质类, 颗粒细胞

Abstract:

Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine disorders in women of reproductive age, and the pathophysiological mechanisms have not been elucidated. Autophagy participates in the all stages of follicular development, in which autophagy is relatively high-activated in the follicular granulosa cells. To maintain the autophagy homeostasis will support ovarian function and regulate follicular development, and ultimately affect the embryo quality and pregnancy outcomes. Abnormal expressions of autophagy-related genes and proteins can activate different pathways of autophagy, inhibit follicular granulosa cell development and interfere with endocrine homeostasis, which participates in the pathological process and prognosis of PCOS. This paper reviews the research progress of key molecules involved in granulosa cell autophagy in endocrine metabolism and the pathological roles of autophagy in PCOS，which provides more references for us to explore the mechanism of PCOS and clinical treatment.

Key words: Polycystic ovary syndrome, Ovarian follicle, Autophagy, Autophagy-related proteins, Granulosa cell

甄佳, 赵紫渊, 王子璐, 师伟, 徐丽. 多囊卵巢综合征病理机制中的颗粒细胞自噬[J]. 国际生殖健康/计划生育杂志, 2024, 43(2): 150-154.

ZHEN Jia, ZHAO Zi-yuan, WANG Zi-lu, SHI Wei, XU Li. Granulosa Cell Autophagy in Pathophysiological Mechanism of Polycystic Ovary Syndrome[J]. Journal of International Reproductive Health/Family Planning, 2024, 43(2): 150-154.

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多囊卵巢综合征病理机制中的颗粒细胞自噬

Granulosa Cell Autophagy in Pathophysiological Mechanism of Polycystic Ovary Syndrome

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