肠道菌群与多囊卵巢综合征代谢异常的研究进展

doi:10.12280/gjszjk.20220045

摘要/Abstract

摘要：

多囊卵巢综合征（polycystic ovary syndrome,PCOS）患者的高雄激素血症、胰岛素抵抗和肥胖之间相互影响,其代谢异常成为PCOS患者急需解决的问题之一。人体肠道中存在着丰富的微生物,肠道菌群与宿主终生相伴,互利共生,成为肿瘤、免疫性疾病和代谢性疾病的研究热点,近年对PCOS患者肠道菌群及其与代谢异常的关系也有一些研究报道。研究表明,PCOS患者肠道菌群与其胰岛素抵抗、高雄激素血症、慢性炎症和代谢综合征发生发展相关,并可能通过短链脂肪酸、脂多糖、性激素和脑-肠轴影响PCOS的临床表现。此外,也有少量临床研究尝试应用粪便微生物群移植、补充益生菌和中药来调节肠道菌群,探讨治疗某些疾病的可能性。

关键词: 多囊卵巢综合征, 肠道菌群, 代谢, 胰岛素抗药性, 治疗

Abstract:

The metabolic abnormality with hyperandrogenemia, insulin resistance and obesity in patients with polycystic ovary syndrome (PCOS) has been a hot topic of study and clinical treatment of PCOS. A complex community of microorganisms resides within the intestine. Gut microbiome and the host life-long companion are the relationship of the mutual benefit symbiosis. In recent years, the correlation between gut microbiome and tumors, immunity, metabolic disease has become a hot topic. Meanwhile, there are increasing literatures on the correlation between gut microbiome and the metabolic abnormality of PCOS patients. Many studies have showed that there are positive correlations between gut microbiome and insulin resistance, hyperandrogenism, chronic inflammation and metabolic syndrome, and that gut microbiome may contribute to the development of clinical features of PCOS by the pathways of short chain fatty acids, lipopolysaccharides, sex hormone levels and the brain-gut axis. In addition, there were also a few clinical studies that the fecal microbiota transplantation, supplementation with probiotics and traditional Chinese medicine were tried to regulate gut microbiome in a small sample test so as to treat some disorders.

Key words: Polycystic ovary syndrome, Gut microbiome, Metabolism, Insulin resistance, Therapy

杨茹, 胡文胜, 包晓燕, 黄烨佩, 叶莎, 黄坚. 肠道菌群与多囊卵巢综合征代谢异常的研究进展[J]. 国际生殖健康/计划生育, 2022, 41(2): 156-159.

YANG Ru, HU Wen-sheng, BAO Xiao-yan, HUANG Ye-pei, YE Sha, HUANG Jian. Research Progress of Gut Microbiome in Patients with Polycystic Ovary Syndrome[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(2): 156-159.

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