昼夜节律紊乱与多囊卵巢综合征的关系

doi:10.12280/gjszjk.20240270

摘要/Abstract

摘要：

昼夜节律通过以24 h为周期的生理振荡使机体适应外界环境变化，并起到调节能量代谢、炎症、细胞更新及肠道微生物群的作用，其功能紊乱会导致女性生殖能力下降。多囊卵巢综合征越来越多地被描述为一种遗传性多基因性状，在暴露于不良生活方式或环境危险因素后表现出来。研究表明现代生活方式中不健康的饮食和睡眠习惯可通过昼夜节律紊乱导致多囊卵巢综合征的发生，其机制可能涉及内分泌和生殖失衡（高雄激素）、代谢改变（胰岛素抵抗、脂代谢异常）、胃肠道微生物组紊乱（生态失调）和遗传因素等。在维持昼夜节律稳定过程中发挥重要作用的基因被称为生物钟基因，可能是预防和治疗多囊卵巢综合征的新靶点。综述昼夜节律紊乱与多囊卵巢综合征发生发展的相关研究，旨在为未来研究及临床治疗提供参考。

关键词: 多囊卵巢综合征, 昼夜节律, 雄激素增多症, 胃肠道微生物组, 遗传

Abstract:

Circadian rhythm adapt the body to the changes of external environment through physiological oscillations on a 24-h cycle, and play a role in regulating energy metabolism, inflammation, cell renewal, and gut microbiota. The dysfunction of circadian rhythm can lead to the reduction of fertility in women. Polycystic ovary syndrome (PCOS) is increasingly described as an inherited polygenic trait that manifests itself after exposure to poor lifestyle or environmental risk factors. Studies have shown that unhealthy dietary and sleep habits in modern lifestyles can contribute to the development of PCOS through circadian rhythm disorders. The mechanisms may involve the endocrine and reproductive imbalances (hyperandrogenism), metabolic alterations (insulin resistance, lipid metabolism abnormalities), disruption of the gastrointestinal microbiome (ecological dysregulation), and genetic factors. Genes that play an important role in the maintenance of circadian rhythm stabilization are known as biological clock genes, and may be novel targets for the prevention and treatment of PCOS. In this paper, we summarize the research on circadian rhythm disorders and the development of PCOS, and provide a reference for future research and clinical treatment.

Key words: Polycystic ovary syndrome, Circadian rhythm, Hyperandrogenism, Gastrointestinal microbiome, Heredity

雷瑞祥, 万怡, 李钰滋, 关德凤, 张学红. 昼夜节律紊乱与多囊卵巢综合征的关系[J]. 国际生殖健康/计划生育杂志, 2024, 43(6): 501-505.

LEI Rui-xiang, WAN Yi, LI Yu-zi, GUAN De-feng, ZHANG Xue-hong. Association of Circadian Rhythm Disorders with Polycystic Ovary Syndrome[J]. Journal of International Reproductive Health/Family Planning, 2024, 43(6): 501-505.

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