子宫内膜异位症相关未破裂卵泡黄素化综合征的研究进展

doi:10.12280/gjszjk.20250053

摘要/Abstract

摘要：

子宫内膜异位症（endometriosis，EMs）是育龄期女性的常见疾病，约30%~50%的EMs患者合并不孕，不孕机制主要包括排卵障碍、卵母细胞质量降低、胚胎发育异常、输卵管和盆腔环境改变等方面，其中未破裂卵泡黄素化综合征（luteinized unruptured follicle syndrome，LUFS）是EMs排卵障碍所致不孕的重要机制之一。EMs通过炎症、氧化应激、内分泌失调和表观遗传异常等途径影响卵泡微环境、颗粒细胞功能以及卵泡发育，导致LUFS发生风险增加。尽管辅助生殖技术（assisted reproductive technology，ART）为EMs患者提供了生育希望，但LUFS的高发生率对卵母细胞的获取也造成了严峻挑战。了解EMs相关LUFS机制，可为EMs药物靶向治疗及ART促进生育的研究提供依据。

关键词: 子宫内膜异位症, 不育, 女（雌）性, 排卵, 排卵诱导, 未破裂卵泡黄素化综合征

Abstract:

Endometriosis (EMs) is a common disease among women of reproductive age, with approximately 30%-50% of EMs patients experiencing infertility. The mechanisms underlying infertility in EMs include ovulation disorders, reduced oocyte quality, abnormal embryo development, alterations in tubal and pelvic environments. Among these mechanisms, the luteinized unruptured follicle syndrome (LUFS) represents a critical mechanism contributing to the infertility caused by ovulation disorders in EMs. EMs can disrupt the follicular microenvironment, granulosa cell function, and follicular development through mutiple pathways involving inflammation, oxidative stress, endocrine dysregulation, and epigenetic abnormalities, thereby increasing the risk of LUFS. Although assisted reproductive technology (ART) offers the hope for EMs patients seeking to conceive, the high incidence of LUFS poses significant challenges for oocyte retrieval. Understanding the mechanisms linking EMs to LUFS can provide a foundation for developing targeted pharmacological therapies and improving ART outcomes in EMs patients.

Key words: Endometriosis, Infertility, female, Ovulation, Ovulation induction, Luteinized unruptured follicle syndrome

张梦宇, 尹耀学, 侯振. 子宫内膜异位症相关未破裂卵泡黄素化综合征的研究进展[J]. 国际生殖健康/计划生育杂志, 2025, 44(3): 253-258.

ZHANG Meng-yu, YIN Yao-xue, HOU Zhen. Research Progress on Luteinized Unruptured Follicle Syndrome in Endometriosis[J]. Journal of International Reproductive Health/Family Planning, 2025, 44(3): 253-258.

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