肿瘤坏死因子-α及其抑制剂在生殖领域的研究进展

doi:10.12280/gjszjk.20250025

摘要/Abstract

摘要：

肿瘤坏死因子-α（tumor necrosis factor-α，TNF-α）作为促炎因子，在生殖系统疾病的发病机制中发挥着重要作用，其过度表达可诱发复发性流产、多囊卵巢综合征和子宫内膜异位症等疾病，最终导致不良妊娠结局。近年来，随着对TNF-α研究的不断深入，TNF-α抑制剂也逐渐进入临床视野，为治疗这些疾病提供了新的方向。研究证实，TNF-α抑制剂能够通过阻断TNF-α与其受体的结合，抑制其生物活性，进而减轻炎症反应和免疫系统的过度激活，从而在复发性流产、多囊卵巢综合征和子宫内膜异位症等多种生殖系统疾病中显示出潜在的治疗价值。目前关于其疗效、安全性以及潜在风险的研究仍处于探索阶段，仍需进一步研究。

关键词: 肿瘤坏死因子α, 肿瘤坏死因子抑制剂, 流产, 习惯性, 多囊卵巢综合征, 子宫内膜异位症

Abstract:

Tumor necrosis factor-α (TNF-α) as a pro-inflammatory factor plays an important role in the pathogenesis of reproductive disease. The overexpression of TNF-α can induce recurrent spontaneous abortion, polycystic ovary syndrome, endometriosis and others, which eventually lead to adverse pregnancy outcomes. In recent years, with the development of TNF-α research, TNF-α inhibitors have gradually entered the clinical field of vision, providing a new direction for the treatment of reproductive diseases. Studies have shown that TNF-α inhibitors can inhibit the biological activity of TNF-α by blocking its binding to its receptor, thereby reducing the inflammation response and the over activation of the immune system. Thus, TNF-α inhibitors have been shown the potential therapeutic value in a variety of reproductive diseases such as recurrent spontaneous abortion, polycystic ovary syndrome, and endometriosis. However, the current research on its efficacy, safety and potential risks is still at the exploratory stage and further research is needed.

Key words: Tumor necrosis factor-alpha, Tumor necrosis factor inhibitors, Abortion, habitual, Polycystic ovary syndrome, Endometriosis

李稳安, 付胜蓝, 侯志金, 孟昱时. 肿瘤坏死因子-α及其抑制剂在生殖领域的研究进展[J]. 国际生殖健康/计划生育杂志, 2025, 44(3): 259-264.

LI Wen-an, FU Sheng-lan, HOU Zhi-jin, MENG Yu-shi. Research Progress on Tumor Necrosis Factor-α and Its Inhibitors in the Field of Reproduction[J]. Journal of International Reproductive Health/Family Planning, 2025, 44(3): 259-264.

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