国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2012, Vol. 31 ›› Issue (6): 439-441.

• 论著 • 上一篇    下一篇

正常月经周期IVF-ET患者助孕情况与睾酮水平的关系


李宇彬, 麦庆云 ,丁晨晖, 周灿权   

  1. 510080 广州，中山大学附属第一医院生殖中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-11-15 发布日期:2012-11-15
  • 通讯作者: 周灿权

The Relation Between the Condition of Normal Menstrual Cycle IVF-ET and Testosterone Levels

LI Yu-bin，MAI Qing-yun，DING Chen-hui，ZHOU Can-quan   

  1. The Reproductive Center，the First Affiliated Hospital of Sun Yat-sen University，Guangzhou 510080，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-11-15 Online:2012-11-15
  • Contact: ZHOU Can-quan

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摘要： 目的：探讨正常月经周期女性在进行体外受精（IVF）周期中其卵巢基础内分泌及助孕周期情况与血清睾酮水平的关系。方法：按一定标准收集2011年3月—2011年7月在中山大学附属第一医院生殖中心行IVF-胚胎移植（ET）治疗的、具有正常月经周期的495例妇女资料。比较患者不同年龄、基础促性腺激素、基础黄体生成激素（LH）、基础卵泡刺激素（FSH）/LH比值、基础雌二醇（E2）分组间的睾酮浓度差别；比较不同血清睾酮水平患者的IVF周期情况。结果：不同年龄、基础FSH/LH比值分组间睾酮差别有统计学意义（均P＜0.05）；而基础促性腺激素、基础LH、基础E2不同分组间睾酮差别无统计学意义（均P＞0.05）。不同睾酮水平组间IVF周期取卵数以及可移植胚胎数差别有统计学意义（均P＜0.05）。结论：血清睾酮水平与年龄、FSH/LH比值以及超促排卵取卵数等卵巢储备评估指标有关联。血清睾酮水平对有正常月经周期的女性IVF周期助孕结局也有影响。

关键词: 睾酮, 受精, 体外, 胚胎移植, 卵巢, 妊娠结局, 月经周期

Abstract: Objective：To investigate the relation between the serum testosterone level and basis ovarian endocrine and infertility treatment condition during IVF cycles in normal menstrual cycle women. Methods：495 cases who had IVF-ET cycles from March 2011 to July 2011 in our center were collected. Cases were divided into groups with different parameters, such as age, basis FSH, basis LH，FSH /LH ratio，and basis E2. Testosterone levels, and treatment of IVF cycles, were meticulously compared. Results：The testosterone levels were statistically different in those sub-groups which divided with age and basal FSH/LH ratio （P＜0.05）, while they were not statistically different in those sub-groups divided with basis FSH，basis LH，FSH/LH ratio， and basis E2（P＞0.05）. Among those groups with different testosterone levels，the numbers of retrieval oocyte and portable embryos in the IVF-ET cycles were significantly different（P＜0.05）. Conclusions：Serum testosterone levels were related to some classic indicators of ovarian reservation，such as age，FSH/LH ratio and oocyte number of super-ovulation. The serum testosterone levels can also influence the IVF-ET treatment results in women with normal menstrual cycle.

Key words: Testosterone, Fertilization in vitro, Embryo transfer, Ovary, Pregnancy outcome, Menstrual cycle