国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2012, Vol. 31 ›› Issue (4): 316-318.

• 综述 • 上一篇    下一篇

肥胖与多囊卵巢综合征的相关分析

张 争,张学红   

  1. 兰州大学第一医院生殖医学研究中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-07-15 发布日期:2012-07-15
  • 通讯作者: 张学红

Analysis of Obesity and Polycystic Ovary Syndrome

ZHANG Zheng，ZHANG Xue-hong   

  1. Research Center of Reproductive Medicine，the First Affiliated Hospital of Lanzhou University，Lanzhou 730000，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-07-15 Online:2012-07-15
  • Contact: ZHANG Xue-hong

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摘要： 多囊卵巢综合征（PCOS）是育龄妇女最常见的临床表现高度异质性的内分泌、代谢疾病，是无排卵性不孕的主要原因之一，发病率占育龄妇女的5%～10%。肥胖与PCOS存在紧密联系。PCOS患者中，约50%存在超重或肥胖，其中大部分表现为腹型肥胖。肥胖与一系列代谢紊乱有关，特别是伴胰岛素抵抗的高胰岛素血症和高雄激素血症，两者在PCOS的病理生理过程中发挥关键作用。肥胖易加重PCOS患者的胰岛素抵抗和高雄激素血症，导致肥胖型PCOS患者更易并发2型糖尿病、心血管疾病等远期并发症，同时因此而产生的多毛、痤疮及不孕等典型表现易导致PCOS患者焦虑、抑郁等心理疾病的发生率升高。

关键词: 多囊卵巢综合征, 肥胖症, 瘦素, 胰岛素抗药性, 雄激素增多症

Abstract: Polycystic ovary syndrome （PCOS） is the most common endocrine and metabolic disorder in fertile-aged women. PCOS，a highly heterogeneous disease in clinical feature，is one of the main causes of infertility due to anovulation，which affects 5% to 10% of fertile-aged women. Obesity is strongly associated with the PCOS. There are about 50% of PCOS women with overweight or obesity，most of them being abdominal obesity. Obesity is related to a series of metabolic disorders，especially hyperinsulinemia with insulin resistance and hyperandrogenism，which play a pivotal role in the pathophysiological mechanisms of PCOS. Obesity can independently exacerbate insulin resistance and hyperandrogenism，which lead to the high risk of type 2 diabetes and cardiovascular disease in obese PCOS women. In addition，hirsutism，acne and infertility，the typical clinical manifestations，could cause the increasing depression and anxiety in PCOS women.

Key words: Polycystic ovary syndrome, Obesity, Leptin, Insulin resistance, Hyperandrogenism