国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2014, Vol. 33 ›› Issue (3): 236-238.

• 论著 • 上一篇    下一篇

卵泡成熟前血清孕酮升高时间与IVF/ICSI-ET妊娠结局

宋瑞芳，苏迎春，杨新红，孙婧   

  1. 450052 郑州大学第一附属医院生殖中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-05-15 发布日期:2014-05-15
  • 通讯作者: 苏迎春

Days of the Elevated Level of Serum Progesterone before Follicular Maturation are Related with Outcomes of IVF/ICSI-ET Treatment

SONG Rui-fang，SU Ying-chun，YANG Xin-hong，SUN Jing   

  1. Reproductive Center of the First Affiliated Hospital，Zhengzhou University，Zhengzhou 450052，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-05-15 Online:2014-05-15
  • Contact: SU Ying-chun

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摘要： 目的：探讨注射人绒毛膜促性腺激素（hCG）日之前血清孕酮升高时间对体外受精（IVF）/胞浆内单精子注射（ICSI）-胚胎移植（ET）患者妊娠结局的影响。方法：回顾性分析郑州大学第一附属医院生殖中心2012年6月—2013年6月经IVF/ICSI-ET治疗共2 905例患者的临床资料。长方案组根据注射hCG日有无直径≥20 mm卵泡分为A组（2 725例）和B组（180例），2组又根据自促排卵日至注射hCG日血清孕酮浓度＞1 ng/mL（1 ng/mL=3.17 nmol/L）时间分为以下3组：孕酮＞1 ng/mL 0 d者分别为A1组（1 788例）和B1组（83例）；孕酮≥1 ng/mL 1～2 d者分别为A2组（717例）和B2组（67例）；孕酮≥1 ng/mL时间≥3 d者分别为A3组（220例）和B3组（30例）。比较各组间的妊娠率。结果：A1、A2、A3组妊娠率分别为55.42%、44.21%和41.81%，差异有统计学意义（P＜0.01）。B1、B2、B3组妊娠率分别为48.19%、47.76%和46.66%，差异无统计学意义（P＞0.05）。结论：IVF/ICSI-ET，hCG日存在直径≥20 mm的卵泡时，随着血清孕酮浓度升高（＞1 ng/mL）时间的增加，临床妊娠率会下降。

关键词: 受精, 体外, 精子注射, 细胞质内, 胚胎移植, 孕酮, 妊娠

Abstract: Objective：To explore the effect of days of the elevated serum progesterone before hCG administration on the outcomes of IVF/ICSI-ET treatment. Methods：2 905 cases of IVF/ICSI -ET treatment, from June 2012 to June 2013, were divided into two groups according to whether finding the follicle（ｓ） of diameter≥20 mm （Group A 2 725 cases, and Group B 180 caｓｅｓ） on the hCG day. Two groups were respectively divided into 3 subgroups according to days of the elevated level of progesterone （＞１ ｎg/mL）． Group A1 （１ ７８８ ｃａｓｅｓ） and B１ （８３ ｃａｓｅｓ） ｈａd 0 day of the elevated level of progesterone. Group A２ （７１７ ｃａｓｅｓ） and B2 （６７ ｃａｓｅｓ） ｈａd 1-2 days of the elevated level of progesterone. Groups A３ （２２０ ｃａｓｅｓ） ａｎｄ Ｂ３ （３０ ｃａｓｅｓ） ｈａd ≥3 days of the elevated level of progesterone. The clinical pregnancy rates of groups were meticulously compared. Results：There was significant difference in the clinical pregnancy rates among the Group A1 (55.42%), A2 (44.21%) and A３ （４１．８１％, Ｐ＜０．０１）． Ｉｎterestingly, there was no significant difference in those rates among the Group B1 （４８．１９％）, B2 （４７．７６％） ａnd B3 （４６．６６％, Ｐ＞０．０5）． Conclusions：The clinical pregnancy rate could decrease following days of the elevated level of serum progesterone （＞１ ng/mL） in those IVF/ICSI-ET patients with the folliclｅ（ｓ） of diameter ≥20 mm on the hCG day.

Key words: Fertilization in vitro, Sperm injections, intracytoplasmic, Embryo transfer, Progesterone, Pregnancy