国际生殖健康/计划生育 ›› 2012, Vol. 31 ›› Issue (5): 349-350.

• 专家论坛 • 上一篇    下一篇

体外培养胚胎生命力的评估

孙海翔   

  1. 210008 南京大学医学院附属鼓楼医院生殖医学中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-09-15 发布日期:2012-09-15

In Vitro Embryo Survivability Assessment

SUN Hai -xiang   

  1. Reproductive Medical Center,Drum TowerHospital Affiliated to Nanjing University Medical School,Nanjing 210008,China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-09-15 Online:2012-09-15

摘要: 种植前胚胎发育能力决定妊娠结局。形态学评估作为无损伤技术,是辅助生殖领域最为常用的评价着床前胚胎活力的方法。完善的胚胎形态学评分标准的建立有利于胚胎发育与种植潜能的预测,为临床妊娠提供保障。每个发育阶段胚胎都有其专有特征,很难单一瞬间辨别出能发育到植入阶段的胚胎,应建立连续胚胎评分系统,将原核评分、早期卵裂及分裂期胚胎评分合计,以选择合适的胚胎进行移植。由于形态学参数并不能够准确反映胚胎的发育潜能,形态学评估指标的精度仍不足够。胚胎研究工作者一直致力于探索能够客观评价胚胎发育潜能的检测手段和观察指标,以期准确评估胚胎的生命力,指导临床方案的调整,同时挑选出发育潜能强劲的优质胚胎进行移植,有效提高辅助生殖技术的临床妊娠结局并减少多胎妊娠。

关键词: 胚胎发育, 胚胎移植, 生殖技术, 辅助, 妊娠

Abstract: The preimplantation embryonic developmental capacity determined the pregnancy outcome.Morphological assessment asa non-invasive technology was the most commonly method in ART to evaluate thepreimplantation embryo vitality. It will provide the prediction of embryonic development and clinical pregnancyto establish the grading standard of oocyte and embryo morphology. There are special characteristics for eachdevelopmental stage of embryos. In general, it is difficult to identify which embryo has the developmentalvitality of the implantation stage embryo at a time point. It is necessary to set up a continuous embryo scoringsystem including the pronuclear score, early cleavage and cleavage stage embryo scores in order to select theproper embryo for transfer morphological parameters could not accurately reflect the potential of embryodevelopment because the accuracy of morphological assessment was still not good enough. Embryo researchershave been devoted to exploring the objective evaluation of embryonic development potential in order to guideclinical protocol adjustments. High-quality embryos were selected for transplantation effectively improved theclinical outcome of assisted reproductive technology and reduced multiple pregnancy.

Key words: Embryonic development, Embryo transfer, Reproductive techniques, assisted, Pregn