国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2012, Vol. 31 ›› Issue (6): 484-486.

• 综述 • 上一篇    下一篇

内脂素与妊娠期糖尿病

刘素新, 霍 琰   

  1. 050051石家庄，河北省人民医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-11-15 发布日期:2012-11-15
  • 通讯作者: 霍 琰

Relationship Between Visfatin and Gestational Diabetes Mellitus

LIU Su-xin，HUO Yan   

  1. Department of Obstetrics and Gynecology，the People′s Hospital of Hebei Province，Shijiazhuang 050051，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-11-15 Online:2012-11-15
  • Contact: HUO Yan

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摘要： 妊娠期糖尿病（gestational diabetes mellitus，GDM）是妊娠期首次发现或出现的不同程度的糖耐量受损。其发生率为1%～10%，可增加剖宫产率，导致巨大儿及肩难产等并发症。GDM以胰岛素抵抗为主，其病因相当复杂。内脂素是一种主要由内脏脂肪组织表达和分泌的肽类物质，在葡萄糖代谢方面发挥一定的作用。而其在人体中的病理生理作用尚存在争议，且大部分仍未被完全认识。最近研究表明，内脂素是与GDM发病机制密切相关的一种脂肪细胞因子，具有胰岛素样活性和炎症因子作用。

关键词: 烟酰胺磷酸核糖转移酶, 糖尿病, 妊娠, 胰岛素抗药性, 肿瘤坏死因子α

Abstract: Gestational diabetes mellitus （GDM）is defined as the glucose intolerance at different degree, which is firstly recognised during pregnancy. GDM affects 1%～10% of all pregnancies. It is associated with the increased rates of cesarean section，macrosomia and shoulder dystocia. Its etiology is relatively complex, while phathophysiological feature is insulin resistance. Visfatin, a peptide predominantly expressed in and secreted from visceral adipose with the effects of mimical insulin and inflammatory factor，has a substantial role in the glucose homeostasis. Recent studies indicated that visfatin was one of the adipocytokines which closely related to the incidence of GDM.

Key words: Nicotinamide phosphoribosyltransferase, Diabetes, gestational, Insulin resistance, Tumor necrosis factor-alpha