国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2012, Vol. 31 ›› Issue (6): 487-490.

• 综述 • 上一篇    下一篇

二甲双胍对多囊卵巢综合征的影响

宁冰雪, 腊晓琳   

  1. 830054 乌鲁木齐，新疆医科大学第一附属医院生殖助孕中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-11-15 发布日期:2012-11-15

Clinical Application of Metformin in Polycystic Ovary Syndrome

NING Bing-xue，LA Xiao-lin   

  1. Reproductive Center，the First Affiliated Hospital of Xinjiang Medical University，Urumqi 830054，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-11-15 Online:2012-11-15

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摘要： 多囊卵巢综合征（PCOS）影响6.8%的育龄女性。胰岛素抵抗和高胰岛素血症在PCOS患者的发病机制中起关键作用，并且是与2型糖尿病和代谢异常相关的高风险因素。根据二甲双胍的作用机制，其能够提高成年PCOS患者胰岛素的敏感性、改善高胰岛素血症，还能控制或调节PCOS的其他临床症状，最常见的作用有减轻体质量、改善胰岛素抵抗、调节月经紊乱和治疗不孕。针对青春期PCOS女性，二甲双胍能够降低胆固醇、三酰甘油，减少腹部及内脏脂肪。对于PCOS妊娠患者来说，使用二甲双胍能够减少其妊娠期糖尿病、妊娠期高血压及先兆子痫的风险，改善新生儿的结局，并且尚无证据表明其对新生儿会产生严重不良反应。总之，现有的数据支持PCOS妇女使用二甲双胍可改善代谢风险及生殖结局。

关键词: 多囊卵巢综合征, 二甲双胍, 胰岛素抗药性, 月经紊乱, 不孕, 糖尿病, 妊娠

Abstract: Polycystic ovary syndrome （PCOS） affects 6.6%-6.8% of women in reproductive age. Insulin resistance and hyperinsulinemia play a critical role in the pathogenesis of PCOS, which are associated with a high risk of type 2 diabetes mellitus and cardiometabolic abnormalities. According to its mechanism, metformin can improve insulin sensitivity，reduce hyperinsulinaemia and mediate other clinical symptoms of adult PCOS patients. Metformin is mainly used for losing weight，alleviating insulin resistance，regulating the menstrual period, and treating infertility. In puberty PCOS patients, metformin is used for reducing cholesterol，triglycerides，abdominal and visceral fat. In PCOS women with pregnant, metformin can lower the risks of gestational diabetes，gestational hypertension，preeclampsia, and improve neonatal outcome without any serious side effects. Overall，many available data supported that metformin could lower the cardiometabolic risk , and improve reproductive outcome, in PCOS women.

Key words: Polycystic ovary syndrome, metformin, Insulin resistance, Menstrual disorder, Infertility, Gestational diabetes mellitus