国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2013, Vol. 32 ›› Issue (1): 9-12.

• 论著 • 上一篇    下一篇

胚胎移植14天血β-hCG及孕激素对IVF-ET妊娠结局的预测

李 艳, 项云改, 张 梅, 马丽影, 谭 丽, 赵冬梅   

  1. 450014 郑州大学第二附属医院生殖中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-01-15 发布日期:2013-01-15
  • 通讯作者: 谭 丽

Prediction of Pregnancy Outcome by Serum β-hCG and Progesterone on the Fourteenth Day After IVF-ET

LI Yan，XIANG Yun-gai，ZHANG Mei，MA Li-ying，TAN Li，ZHAO Dong-mei   

  1. Center of Reproductive Medicine，the Second Affiliated Hospital of Zhengzhou University，Zhengzhou 450014，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-01-15 Online:2013-01-15
  • Contact: TAN Li

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摘要： 目的：探讨体外受精-胚胎移植（IVF-ET）后14 d血清人绒毛膜促性腺激素β亚单位（β-hCG）和孕酮对妊娠早期结局的预测价值。方法：回顾性分析2010年4月—2011年11月IVF/胞浆内单精子注射（ICSI）的554例患者胚胎移植后14 d的血清β-hCG和孕酮水平。根据早期妊娠结局的不同分为正常妊娠组（包括单胎和多胎组）、异常妊娠组（包括妊娠早期流产、异位妊娠、生化妊娠）及未妊娠组，比较各组β-hCG和孕酮的水平。结果：①ET 14 d正常妊娠组血清β-hCG高于妊娠早期流产组、异位妊娠组、生化妊娠组和未妊娠组，除妊娠早期流产组与异位妊娠组间血清β-hCG差异无统计学意义（P＞0.05）外，其余各组两两比较差异均有统计学意义（P＜0.05）。②正常妊娠组血清孕酮高于异常妊娠组和未妊娠组（P＜0.05）；多胎妊娠组血清孕酮高于单胎妊娠组（P＜0.05）。③单次β-hCG＞197.27 IU/L时，正常妊娠的可能性为88.9%。β-hCG＞613.94 IU/L，妊娠结局较好，但有多胎妊娠的可能。结论：ET 14 d血清β-hCG和孕酮可作为预测IVF-ET后早期妊娠结局的良好指标。

关键词: 受精, 体外, 胚胎移植, 妊娠结局, 绒毛膜促性腺激素, 孕激素

Abstract: Objective：To investigate the predictive value of serum β-hCG and progesterone （P4） for the early pregnancy outcome on the fourteenth day after in vitro fertilization and embryo transfer （IVF-ET）. Methods：The levels of serum β-HCG and P4 of 554 patients treated with IVF/introcytoplasm sperm injection （ICSI） in our center from April 2010 to November 2011 were analyzed retrospectively. Patients were divided into the normal pregnancy group，the abnormal pregnancy group and the non-pregnant group. The normal pregnancy included single pregnancy and multiple pregnancy. The abnormal pregnancy included early pregnancy miscarriage，ectopic pregnancy and biochemical pregnancy. The differences of β-hCG and P4 among groups were compared. Results：①The level of serum β-hCG in the normal pregnancy group was higher than those in the early abortion/ectopic pregnancy group，the biochemical pregnancy group and non-pregnant group（P＜0.05）. There was no statistical differences of β-hCG between the early abortion group and ectopic pregnancy group（P＞0.05）. ②The level of serum P4 in the normal pregnancy group was higher than those in the abnormal pregnancy group and the non-pregnant group （P＜0.05）, while the level in the multiple pregnancy group was significantly higher than that in the singleton pregnancy group （P＜0.05）. ③When the level of β-hCG of single test was＞197.27 IU/L, the possibility of normal pregnancy was 88.9%. When the level of β-hCG of single test was＞613.94 IU/L，there were a better pregnancy outcome and a higher possibility of multiple pregnancy. Conclusions：Serum β-hCG and progesterone on the fourteenth day after transplantation can be used as the good combined markers of early pregnancy outcome of IVF-ET.

Key words: Fertilization in vitro, Embryo transfer, Pregnancy outcome, Chorionic gonadotropin, Progestins